Milad Baradaran-Ghahfarokhi
*1 Medical Physics and Medical Engineering Department and Medical Student’s Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Corresponding author: Milad Baradaran-Ghahfarokhi, Medical Physics and Medical Engineering Department Isfahan University of Medical Sciences, Isfahan, Iran., Email:
mbaradaran@edc.mui.ac.ir
Abstract
Implication for health policy/practice/research/medical education
Radiotherapy with or without chemotherapy for pelvic malignancies such as gastrointestinal cancers, gynecologic cancers, lymphomas, and sarcomas of the upper abdomen and during total body irradiation may result in radiation-induced kidney injury. The incidence of clinical radiation nephropathy has increased with the use of total-body irradiation in preparation for bone marrow transplantation. Radiation nephropathy usually manifests as proteinuria, hypertension and impairment in urine concentration. The precise pathogenic mechanisms and/or mediators involved in radiation nephropathy remain under active investigation. However, radiation nephropathy is no longer viewed as inevitable, progressive, and untreatable.