eISSN: 2345-2781  



First published online: 01 Mar 2013
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J Renal Inj Prev. 2013;2(1).
doi: 10.12861/jrip.2013.07
PMID: 25340116
PMCID: PMC4205998

Original Article

Histopathological study of the combination of metformin and garlic juice for the attenuation of gentamicin renal toxicity in rats

Azar Baradaran 1, Mahmoud Rafieian-kopaei 2 *

1 Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Prof. Mahmoud Rafieian-Kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. Email: rafieian@yahoo.com

Abstract

Introduction: Tubular toxicity is one of the most important side effects of aminoglycoside antibiotics, especially gentamicin.Objectives: We histopathologically studied the effect of garlic extract and metformin co-administration, in attenuation of genetamicin induced tubular toxicity in rats.Materials and Methods: In this study seventy rats were divided into seven equal groups and except group 1 (control) were injected 100 mg/kg/day gentamicin (GM) intraperitoneally (i.p.) for 10 days. Other than GM, group III received 20 mg/kg garlic (i.p.), group IV metformin (MF) (100 mg/kg, orally), group V a combination of MF with garlic juice (100 and 20 mg/kg/day, respectively) and group VI a combination of MF and garlic juice (50 and 10 mg/kg/day, respectively) for following 10 days. Group VII received a combination of MF and garlic juice (100 and 20 mg/kg, respectively) along with GM. Animals were sacrificed on the 20th day of the experiment and the kidneys were removed for histological examinations.Results: GM induced nephrotoxicity and garlic or MF alone and a combination of both with high doses (not low doses) significantly abolished the kidney tubular injury induced by GM. In addition, co-administration of GM, MF and garlic (group 7) prevented the GM- induced tissue damage more than the groups in which MF and garlic were injected 10 days post GM administration.Conclusion: Garlic extract and Metformin, alone or in a combination, might be safely used to ameliorate GM induced tubular toxicity.
Implication for health policy/practice/research/medical education: Garlic extract and Metformin, alone or in a combination, might be safely used to ameliorate gentamicin induced tubular toxicity.

Please cite this paper as: Baradaran A, Mahmoud Rafieian-kopaei M.Histopathological study of the combination of metformin and garlic juice for the attenuation of gentamicin renal toxicity in rats. J Ren Inj Prev 2013; 2(1): 15-21.
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