eISSN: 2345-2781  
J Renal Inj Prev. 2014;3(1).
doi: 10.12861/jrip.2014.10
PMID: 25340161
PMCID: PMC4206038

Original Article

Efficacy of supplementary vitamin D on improvement of glycemic parameters in patients with type 2 diabetes mellitus; a randomized double blind clinical trial

Hamid Nasri 1, Saeed Behradmanesh 2, Ahmad Reza Maghsoudi 2, Ali Ahmadi 3, Parto Nasri 4, Mahmoud Rafieian-Kopaei 5 *

1 Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Prof. Mahmoud Rafieian-kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Email: rafieian@yahoo.com

Abstract

Introduction: Studies have revealed the association between vitamin D deficiency and changes in blood glucose and insulin levels as well as sensitivity of the target tissues to insulin. Objective: In this study, we examined the effect of adding vitamin D (cholecalciferol ; 50,000 units) to therapeutic regimen of T2DM patients compared to placebo on regulating the blood glucose and glycemic parameters. Patients and Methods: This study was a double blind clinical trial conducted on 60 type 2 diabetes mellitus (T2DM) patients. Exclusion criteria were taking calcium, vitamin D supplements or any drugs effecting calcium and vitamin D metabolism in the past 6 months. Serum 25-Hydroxy vitamin D [25(OH)D] level was measured with ELISA method. Patients were administered weekly vitamin D supplementation (50000 units) for 12 weeks. Results: There was no significant relation between HbA1c and 25(OH)D level prior the study (p> 0.05). After intervention, 25(OH)D level in interventional group was significantly higher compared to that of control group. HbA1c in male interventional group was significantly less than that of control group (p= 0.0068). Conclusion: Weekly vitamin D supplementation had beneficial effect on glycemic parameters in male type 2 diabetic patients.

Implication for health policy/practice/research/medical education:

In this study we found that weekly vitamin D supplementation (cholecalciferol; 50,000 units for 12 weeks) had beneficial effect on HbA1c of male type 2 diabetic patients. Thus, oral vitamin D may help in improvement of glycemic control in these patients.

Please cite this paper as: Nasri H, Behradmanesh S, Maghsoudi AR, Ahmadi A, Nasri P, Rafieian-Kopaei M. Efficacy of supplementary vitamin D on improvement of glycemic parameters in patients with type 2 diabetes mellitus; a randomized double blind clinical trial. J Ren Inj Prev 2014; 3(1):31-34. DOI: 10.12861/jrip.2014.10

First name
 
Last name
 
Email address
 
Comments
 
Security code