eISSN: 2345-2781  
J Renal Inj Prev. 2015;4(3).
doi: 10.12861/jrip.2015.20
PMID: 26468483
PMCID: PMC4594212

Original Article

Hypercalciuria following ceftriaxone a fact or myth

Anoush Azarfar 1, Mohammad Esmaeeli 1, Yalda Ravanshad 2 * , Sepideh Bagheri 1, Ezzat Khodashenas 1, Fatemeh Ghane-Sharbaf 1, Majid Malaki 3, Amir-Hossein Mohamadian 1

1 Department of Pediatric Nephrology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Clinical Research Development Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding author: Yalda Ravanshad, Email: ravanshady@mums.ac.ir

Abstract

Introduction: Nephrolithiasis is a common worldwide problem both in children and adults. Ceftriaxone as a widely used antibiotic can contribute to the formation of renal stones and hypercalciuria.

Objectives: To find the effect of ceftriaxone, a widely used antibiotic, on urinary calcium excretion rate in children.

Patients and Methods: 84 infants and children over 3 months admitted to hospital for non-renal problems. They were all previously healthy children affected with a condition mandating hospitalisation. They were randomly divided into 2 groups; those who received ceftriaxone according to their physician decision as the case group and those who did not receive antibiotics as the control group. The patients urinary calcium excretion was determined as calcium to creatinine ratio in a random urine sample in the first and third day of their admission. All data was expressed by mean ± SD and analysed by t independent and chi-square tests by SPSS 16. P value less than 0.05 was significant.

Results: Eighty-four cases were analysed. Calcium excretion in received and non-received ceftriaxone groups was 0.13 ± 0.06 and 0.14 ± 0.02 respectively at first day of admission (P = 0.1). After 3 days, the urine calcium to creatinine ratio increased to 0.27 ± 0.2 and 0.26 ± 0.08 in received and non- received ceftriaxone groups (P = 0.8).

Conclusion: In children, urinary calcium excretion increases 2 times in average in a short time after admission because of gastroenteritis, and ceftriaxone is not different to other antibiotics for increase urinary calcium excretion in 3 days after admission.

Implication for health policy/practice/research/medical education:

While ceftriaxone is a widely used antibiotic, we aimed to test whether it could contribute to the formation of renal calculi. Results of the current study showed that urinary calcium excretion does not significantly rise after ceftriaxone administration.

Please cite this paper as: Azarfar A, Esmaeeli M, Ravanshad Y, Bagheri S, Khodashenas E, Ghane-Sharbaf F, et al. Hypercalciuria following ceftriaxone a fact or myth. J Renal Inj Prev. 2015; 4(3): 101-103. DOI: 10.12861/jrip.2015.2

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