eISSN: 2345-2781  
. 2017;6(3):158-163.
doi: 10.15171/jrip.2017.31

Review Article

A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells

Mohammad Reza Mahmoudian-Sani 1, Majid Asadi-Samani 2 * , Tahra Luther 3, Ali Saeedi-Boroujeni 4, Neda Gholamian 5

1 Research Center for Molecular Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
2 Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of General Surgery, University of Michigan, Ann Arbor, MI, USA
4 Department of Immunology, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Majid Asadi-Samani, Email: biology_2011@yahoo.com

Abstract

Type 1 diabetes (T1D), which resulting in hyperglycemia, is an autoimmune disease. This disease characterized by destruction of the insulin-secreting cells of the islets of Langerhans. The CD4 T regulatory cells (Tregs) are important for prevention of disease. Treg cells (defined as CD4+CD25+Foxp3+) have been found to play a critical role in maintaining self-tolerance and preventing autoimmune diseases. Dysfunction and decreased numbers of Tregs may lead to the development of T1D. This review article aimed to report medicinal plants and their nature-based derivatives that are effective on regulation of Tregs activity in diabetes patients. The EndNote software, Web of Science and PubMed databases were searched from 2000 through 2016 for publications on role of Tregs in diabetes. It was found that Uncaria tomentosa, Dioscorea alata, Cordyceps sinensis, Origanum vulgare, TJ-48, compound K, azaspirane, lisofylline, and curcumin can promote the function of Tregs in T1D. The reported medicinal plants and their derivatives are rich resources for diabetes treatment. They can be used more extensively for diabetes patients if be evaluated in clinical trials.

Implication for health policy/practice/research/medical education:

The medicinal plants and their derivatives that are effective on regulation of Tregs activity can prevent and treat the diabetes. Uncaria tomentosa, Dioscorea alata, Cordyceps sinensis, Origanum vulgare, TJ-48, compound K, azaspirane, lisofylline, and curcumin have been reported to regulate the function of Tregs in type 1 diabetes (T1D). Therefore they can be used in discovering new drugs for prevention and treatment of T1D.

Please cite this paper as: Mahmoudian-Sani MR, Luther T, Asadi-Samani M, Saeedi-Boroujeni A, Gholamian N. A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells. J Renal Inj Prev. 2017;6(3):158-163. DOI: 10.15171/jrip.2017.31.

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