eISSN: 2345-2781  



First published online: 22 Nov 2016
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J Renal Inj Prev. 2017;6(1):56-60.
doi: 10.15171/jrip.2017.10
PMID: 28487873
PMCID: PMC5414520
Scopus id: 85029543758

Original Article

Renal biochemical and histopathological alterations of diabetic rats under treatment with hydro alcoholic Morus nigra extrac

Mohammad Rahimi-Madiseh 1, Azar Naimi 2, Esfandiar Heydarian 3, Mahmoud Rafieian-Kopaei 1 *

1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Mahmoud Rafieian-Kopaei, Email: rafieian@yahoo.com

Abstract

Introduction: Morus nigra fruit is known to have antioxidant effects and used to control the blood sugar level in traditional medicine.

Objectives: This study was conducted to investigate the biochemical and histopathological changes in the serum and kidneys of diabetic rats treated with hydroalcoholic M. nigra extract.

Materials and Methods: In this study, 60 male Wistar rats were divided into five groups of 12 each. After induction of diabetes with alloxan, the diabetic rats were treated with hydroalcoholic extract of M. nigra at different concentrations. Then, the animals were anesthetized and the serum levels of glucose, creatinine, and urea as well as kidney tissue catalase level measured. The kidney tissue was also histopathologically examined.

Results: Milder glomerular damage was seen in the group treated with 800 mg/kg of the M. nigra extract compared with diabetic and positive controls, and no difference in the expansion of mesenchymal tissue into renal glomerular vessels observed between the group treated with 800 mg/kg of M. nigra extract and diabetic and positive controls. Furthermore, creatinine levels were significantly higher and urea levels significantly lower in the group treated with 800 mg/kg of M. nigra extract than healthy and positive control groups (P<0.05).

Conclusion: Administration of M. nigra extract at 800 mg/kg can prevent kidney tissue damage in diabetic rats and this fruit seems to be beneficial to patients with diabetes.

Implication for health policy/practice/research/medical education:

Administration of M. nigra extract at 800 mg/kg can prevent kidney tissue damage in diabetic rats and this fruit seems to be beneficial to patients with diabetes.

Please cite this paper as: Rahimi-Madiseh M, Naimi A, Heydarian E, Rafieian-Kopaei M. Renal biochemical and histopathological alterations of diabetic rats under treatment with hydro alcoholic Morus nigra extract. J Renal Inj Prev. 2017;6(1):56-60. DOI: 10.15171/jrip.2017.10

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