eISSN: 2345-2781  



First published online: 18 Dec 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Abstract Page Views: 136
PDF Downloads: 46
Full Text Views: 0
. 2017;6(2):127-131.
doi: 10.15171/jrip.2017.25
PMID: 28497089
PMCID: PMC5423280

Original Article

Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial

Majid Shirani-Boroujeni 1, Saeed Heidari-Soureshjani 2, Zahra Keivani Hafshejani 3 *

1 Department of Surgery, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 MSc, Research and Technology Deputy, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Nursing, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Zahra Keivani, Email: keivaniz@yahoo.com

Abstract

Introduction: Benign prostatic hyperplasia (BPH) is considered as a major cause of lower urinary tract symptoms (LUTS) in older men and its most common sign is nocturia.

Objectives: This study aimed to determine the effect of the seeds of Peganum harmala compared with tamsulosin on alleviating urinary symptoms in patients with BPH.

Patients and Methods: In this single blind clinical trial study, 90 patients diagnosed with BPH and LUTS, based on international prostate standard survey (IPSS) were divided into three groups. The first group was received oral capsule of P. harmala, the second group was administered tamsulosin with oral P. harmala seed and the third group was received tamsulosin drug and they were evaluated after 4 weeks.

Results: The results showed that the difference between mean scores of IPSS was significant after the intervention (P=0.001). Besides, the mean of IPSS in the three groups was significantly different (P=0.001) (the first group 41.9±5.3, the second group 21.0±4.4 ,the third group 16.5±3.7 respectively). However, after the intervention, patients in the second group had the lowest average on most indicators of IPSS but the difference was only significant about urinary frequency, nocturia and intermittency(P<0.05).

Conclusion: Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with BPH.

Implication for health policy/practice/research/medical education:

Peganum harmala can be administered as a herbal remedy for improving urinary symptoms of benign prostate enlargement.

Please cite this paper as: Shirani-Boroujeni M, Heidari-Soureshjani S, Keivani Hafshejani Z. Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial. J Renal Inj Prev. 2017;6(2):127-131. DOI: 10.15171/jrip.2017.25.

First name
 
Last name
 
Email address
 
Comments
 
Security code