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Journal of Renal Injury Prevention 2017;6(2):132-136. doi:10.15171/jrip.2017.26
Association between prostate specific antigen levels and coronary artery angioplasty

Original Article

Arezoo Khosravi 1, Eghlim Nemati 2 * , Mahdi Soleimanian 1, Neda Raesi 1, Shahin Abbaszadeh 2

1 Atherosclrosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran


*Corresponding author: Eghlim Nemati,
Email: nemati203@yahoo.com

Abstract

Introduction: Prostate-specific antigen (PSA) is a protein, whose serum levels changes during various physiologic and pathologic situations. Recently, the relationship between PSA and cardiologic disorders has been assessed.

Objectives: The purpose of this study was to assess the association of percutaneous coronary intervention (PCI) complications with PSA serum levels.

Patients and Methods: In this study, 100 eligible patients undergoing PCI were included. The total PSA serum values were analyzed pre- and post-procedure. The association between PSA levels with age, gender, inflammatory (C-reactive protein [CRP] and white blood cell [WBC]), cardiogenic (troponin, CK-MB, echocardiography and angiography results), and nephrology (creatinine) properties was investigated.

Results:  Changes in the level of PSA pre- and post-PCI was not significant (P=0.2). However, based on the pathology, patients with acute coronary syndrome (ACS) had a significant difference in the levels of PSA  compared to cases of stable ischemic heart disease (SIHD) (P=0.008). Moreover, the effect of gender on the changes in PSA level following PCI was conclusive. There was no  association between the direct effect of PCI parameters or PCI complications on PSA level changes. 

Conclusion: The results showed that PSA levels were affected by the etiology of cardiac disorders instead of therapeutic methods like PCI.



Notes

Implication for health policy/practice/research/medical education:

In an investigation, total PSA serum values before and after the procedure were examined. We observed that differences in the levels of PSA before and after PCI was not significant. However, based on the pathology, patients with ACS had a significant discrepancy in the level of PSA compared to cases of SIHD.

Please cite this paper as: Khosravi A, Nemati E, Soleimanian M, Raesi N, Abbaszadeh S. Association between prostate specific antigen levels and coronary artery angioplasty. J Renal Inj Prev. 2017;6(2):132-136. DOI: 10.15171/jrip.2017.26.


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Creative Commons Attribution 4.0 License This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright © 2016 The Author(s)
Published by Nickan Research Institute