eISSN: 2345-2781  
. 2017;6(2):142-147.
doi: 10.15171/jrip.2017.28
PMID: 28497092
PMCID: PMC5423283

Original Article

The relationship between dialysis adequacy and serum uric acid in dialysis patients; a cross-sectional multi-center study in Iranian hemodialysis centers

Eghlim Nemati 1, Arezoo khosravi 2 * , Behzad Einollahi 1, Mehdi Meshkati 3, Mehrdad Taghipour 1, Shahin Abbaszadeh 1

1 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Atherosclrosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
3 Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
*Corresponding author: Arezoo Khosravi, Email: arekhosravi@yahoo.com

Abstract

Introduction: Uric acid is one of the most significant uremic toxins accumulating in chronic renal failure patients treated with standard dialysis. Its clearance has not any exact relation with urea and creatinine clearance.

Objectives: The aim of this study was to investigate the relationship between adequacy of dialysis and serum level of uric acid in dialysis patients of some dialysis centers in Iran.

Patients and Methods: In this study 1271 hemodialysis patients who have been treated for more than 3 months were evaluated. Their information and examinations from their files in all over the country were gathered and analyzed using SPSS versin18.0.

Results: In this study, a significant relationship between dialysis duration and serum level of uric acid was not detected, however, a significant relationship between patients Kt/V and uric acid (R=0.43, P=0.029) was seen. Patients who had higher adequacy of dialysis had a higher level of plasma uric acid.

Conclusion: For better controlling of plasma uric acid level of hemodialysis patients, increasing of the adequacy of dialysis or its duration is not effective. Other modalities of decreasing of serum uric acid like, changing diet or lifestyle or medical therapy may be necessary.

Implication for health policy/practice/research/medical education:

In this research 1271 hemodialysis patients who have been treated for more than three months were included and the association between adequacy of dialysis and serum level of uric acid in some dialysis centers in Iran evaluated. No significant relationship in dialysis duration with serum level of uric acid was seen. However, there was a significant association between patients’ Kt/V and uric acid was detected.

Please cite this paper as: Nemati E, Khosravi A, Einollahi B, Meshkati M, Taghipour M, Abbaszadeh S. The relationship between dialysis adequacy and serum uric acid in dialysis patients; a cross-sectional multi-center study in Iranian hemodialysis centers. J Renal Inj Prev. 2017;6(2):142-147. DOI: 10.15171/jrip.2017.28.

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