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Journal of Renal Injury Prevention 2017;6(2):148-152. doi:10.15171/jrip.2017.29
Association between abnormal serum free light chains ratio and known prognostic factors in lymphoma; a nephrology viewpoint

Original Article

Minoosh Moghimi 1,2, Mahshid Kashkooli Behroozi 3, Mehdi Maghbooli 4, Sattar Jafari 1,2, Saeideh Mazloomzadeh 5, Aiyoub Pezeshgi 1 *

1 Department of Hematology-Oncology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2 Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
3 Department of Oncology, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Neurology, Zanjan University of Medical Sciences, Zanjan, Iran
5 Department of Epidemiology, Zanjan University of Medical Sciences, Zanjan, Iran


*Corresponding author: Aiyoub Pezeshgi,
Email: Dr.a.pezeshki@gmail.com

Abstract

Introduction: The serum immunoglobulin free light chain (FLC) assay quantities of free kappa (??) and lambda (??) light chains. This assay has prognostic value in plasma cell proliferative disorders. There are limited data on serum FLC in B-cell malignancies.

Objectives: The aim of this study was to compare the known prognostic factors in non-Hodgkin’s lymphoma of the type B-cell and Hodgkin disease with an abnormal secretion amount of light chains in these lymphomas.

Patients and Methods: The association of pretreatment FLC and FLC ratio (??) with previously known prognostic factors for lymphoma such as the international prognostic index (IPI) and B symptoms were evaluated in 50 patients with Hodgkin’s and non-Hodgkin’s lymphoma. IPI is a prognostic score given based on the clinical variables including age, disease stage, serum LDH and extra-nodal involvement. Elevated FLC and an abnormal ??? ratio was defined based on the previous publications.

Results: The prevalence of abnormal FLC ratio was 38% in all patients and 40.9% in patients with diffuse large B-cell lymphoma. Abnormal FLC ratio was significantly associated with IPI (P=0.04) and B symptoms (P=0.02) in both groups of the patients with Hodgkin’s and non-Hodgkin’s lymphoma. The stage of the disease in Hodgkin’s lymphoma patients showed a significant relationship with the abnormal FLC ratio (P=0.04). Presence of the B symptoms in patients with Hodgkin’s lymphoma had a modest but not statistically significant association with the abnormal FLC ratio (P=0.07).

Conclusion: Abnormal FLC ratio as a new potent prognostic biomarker has a significant association with IPI which is the most common clinical tool used to predict outcome in lymphoma patients. Since there is a need for developing a reliable and quantitative prognostic biomarker for lymphoma, evaluation of the independent effect of the abnormal serum FLC ratio is suggested to be considered in future prospective studies. The result of these studies will also be useful for nephrologists, while serum immunoglobulin FLC is capable to damage kidney.



Notes

Implication for health policy/practice/research/medical education:

The findings of the current study indicated that kappa to lambda ratio may be useful as a prognostic factor for B cell and Hodgkin’s lymphoma patients. However confirming this relationship in Hodgkin’s and other B cell lymphomas needs more prospective studies with more participants involved. The result of these studies will also be useful for nephrologists, while serum immunoglobulin FLC is capable to damage kidney.

Please cite this paper as: Moghimi M, Kashkooli Behroozi M, Maghbooli M, Jafari S, Mazloomzadeh S, Pezeshgi A. Association between abnormal serum free light chains ratio and known prognostic factors in lymphoma; a nephrology viewpoint. J Renal Inj Prev. 2017;6(2):148-152. DOI: 10.15171/jrip.2017.29.


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Published by Nickan Research Institute