eISSN: 2345-2781  
. 2017;6(3):184-187.
doi: 10.15171/jrip.2017.35

Original Article

Anti-inflammatory effects of grape seed extract in hemodialysis patients; a pilot study

Amir Hesam Alirezaei 1, Alireza Shirzadeh Barough 1 * , Tabassom Azizi 1, Siavash Shirzadeh Barough 1, Amir Ghorbanihaghjo 2, Nadereh Rashtchizadeh 3, Hossein Babaie 2, Abbas Delazar 2

1 Department of Nephrology, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Biochemistry Lab, Drug Applied Research Center, Tabriz University of medical Siences, Tabriz, Iran
3 Biomedical Section, Medical Faculty, Tabriz University of medical Siences, Tabriz, Iran
*Corresponding author: Amir Hessam Alirezaei, Email: amirhesam124@gmail.com

Abstract

Introduction: Immune responses and inflammation are major risk factors for mortality in patients with end-stage renal disease (ESRD). Increased oxidative stress is a common feature of ESRD, and it has been speculated that it is interrelated to inflammation. In many studies it has been proved that red grape seed extract (RGSE) provides an antioxidant efficacy.

Objectives: The aim of this study was to investigate the anti-inflammatory effects of RGSE in hemodialysis patients.

Patients and Methods: Thirty hemodialysis individuals were divided into two groups that received either 200 mg/day of the RGSE or placebo for one month. Mean ± SD of age of patients was 58.5 ± 10.5 years. Duration of dialysis was 4 ± 3.4 years and 27 patients were male and 3 patients were female. After a 2-week washout period, the groups were crossed over for another one month. Markers of inflammation, lipid profiles and blood factors were measured at baseline after intervention with RGSE or placebo.

Results: Our results showed that RGSE consumption could not make statistically significant changes in markers of inflammation, lipid profiles and blood factors in hemodialysis patients.

Conclusion: Although RGSE could not improve markers of inflammation, lipid profiles and blood factors in hemodialysis subjects over a 1 month period. However, this result may be due to short period of treatment or low dose of RGSE. Further studies need to clear these contradictions

Implication for health policy/practice/research/medical education:

In a study on 30 hemodialysis patients, we found, RGSE could not improve markers of inflammation, lipid profiles and blood factors over one month period. However, this result may be due to short period of treatment or low dose of RGSE. Further studies need to clear these contradictions.

Please cite this paper as: Alirezaei AH, Shirzadeh Barough A, Azizi T, Shirzadeh Barough S, Ghorbanihaghjo A, Rashtchizadeh N, Babaie H, Delazar A. Anti-inflammatory effects of grape seed extract in hemodialysis patients; a pilot study. J Renal Inj Prev. 2017;6(3):184-187. DOI: 10.15171/jrip.2017.35.

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