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Journal of Renal Injury Prevention 2017;6(3):192-198. doi:10.15171/jrip.2017.37
Incidence of contrast-induced nephropathy a prospective study

Original Article

Sameer Peer * , Naseer Ahmad Choh, Tariq Ahmad Gojwari

1 Department of Radiodiagnosis and Imaging, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India


*Corresponding author: Sameer Peer,
Email: sameer.peer602@gmail.com

Abstract

Introduction: Contrast-induced acute kidney injury (AKI) is one of the most common causes of hospital-acquired AKI.

Objectives: To determine the incidence of contrast induced nephropathy (CIN), to identify significant risk factors associated with CIN and to compare the variations in serum creatinine levels with and without contrast exposure.

Patients and Methods: A total of 222 patients (124 males and 98 females with mean age of 48.96 ± 16.74 years) who received iodinated contrast agents during different procedures over a period of 18 months were included in the study. CIN was defined as a relative increase of >25% or an absolute increase of > 0.5 mg/dL in serum creatinine levels 4 days post- procedure. 148 patients (82 males and 66 females with mean age of 47.48 ± 17.21 years) who did not receive any contrast agent were included as controls to determine the frequency with which the variations in serum creatinine levels fulfilled the definition of CIN.

Results: The overall incidence of CIN was 12.6%. Incidence of CIN was 32.6% after percutaneous coronary intervention (PCI) and 7.38% after IV contrast exposure (P < 0.0001). Multivariate logistic regression analysis of risk factors revealed heart failure (P = 0.001), pre-procedure serum creatinine level ≥ 1.5 mg/dL (P = 0.005) and nature of contrast agent (P = 0.001), as independent risk factors of CIN. 2.02% patients in control group showed variations in serum creatinine levels within the range corresponding to the definition of CIN.

Conclusion: Heart failure, pre-procedural serum creatinine of ≥ 1.5 mg/dL and the nature of contrast agent are independent predictors of CIN.



Notes

Implication for health policy/practice/research/medical education:

Contrast induced AKI is one of the most common causes of hospital-acquired AKI. Most of the prospective studies lack a control group for comparison. This study evaluates the epidemiology of CIN and compares the findings with a matched control group. Heart failure, pre-procedure serum creatinine level ≥1.5 mg/dL and nature of contrast medium used can independently predict the likelihood of Contrast-induced nephropathy.

Please cite this paper as: Peer S, Choh NA, Gojwari TA. Incidence of contrast-induced nephropathy a prospective study. J Renal Inj Prev. 2017;6(3):192-198. DOI: 10.15171/jrip.2017.37.


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Copyright © 2016 The Author(s)
Published by Nickan Research Institute