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Journal of Renal Injury Prevention 2017;6(3):231-235. doi:10.15171/jrip.2017.43
Urinary level of interleukin-1alpha and interleukin-6 in patients underwent extracorporeal shock wave lithotripsy

Original Article

Mohsen Rajabnia Chenari 1, Faramarz Fazeli 2 * , Mehdi Jahantigh 3, Javid Dehghan 4, Amin Zarghami 5, Mohammad Bahadoram 6,7, Ali Ghorbani 6, Sajedeh Mirshahvalad 8

1 Department of Internal Medicine, Kurdistan University of Medical Sciences, Kurdistan, Iran
2 Department of Urology, Zahedan University of Medical Sciences, Zahedan, Iran
3 Department of Pathology, Zahedan University of Medical Sciences, Zahedan, Iran
4 Department of Community Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
5 Iranshahr University of Medical Sciences, Iranshahr, Iran
6 Chronic Renal Failure Research Center, Department of Internal Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7 Student Research Committee, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
8 Student Research Committee, Babol University of Medical Sciences, Babol, Iran


*Corresponding author: Dr. Faramarz Fazeli,
Email: fazeli88@yahoo.com

Abstract

Introduction: Extracorporeal shock wave lithotripsy (ESWL) was established as a dramatic procedure in the treatment of urinary stones. According to the growing utilization of ESWL as a major method of urinary stone, management and the reports have been reported based on renal tissue damage.

Objectives: We decided to examine the severity of ESWL-induced renal tissue damage and its related factors by monitoring the urinary levels of cytokines.

Patients and Methods: In this study, the urinary samples of 32 patients with urolithiasis were taken before, 24 hours and 14 days after ESWL and interleukin-1ɑ (IL-1a) and interleukin-6 (IL-6) levels were measured by enzyme-linked immunosorbent assay (ELISA) method.

Results: Our findings indicated that there was a significant difference between the urinary levels of both IL-1ɑ and IL-6 in 14 days before and after ESWL.

Conclusion: According to our results, ESWL leads to an inflammatory process in the urinary tract and the inflammation have continuously increased up to 14 days after procedure.



Notes

Implication for health policy/practice/research/medical education:

Findings of the current study highlighted the underlying inflammatory process following extracorporeal shock wave lithotripsy (ESWL) procedure and can be a good sample for further investigations.

Please cite this paper as: Rajabnia Chenari M, Fazeli F, Jahantigh M, Dehghan J, Zarghami A, Bahadoram M, et al. Urinary level of interleukin-1alpha and interleukin-6 in patients underwent extracorporeal shock wave lithotripsy. J Renal Inj Prev. 2017;6(3):231-235. DOI: 10.15171/jrip.2017.43.


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Published by Nickan Research Institute