eISSN: 2345-2781  
Submitted: 28 Apr 2017

Accepted: 10 Sep 2017
First published online: 29 Sep 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Abstract Page Views: 670
PDF Downloads: 1347
Full Text Views: 0
J Renal Inj Prev. 2017;6(4):297-302.
doi: 10.15171/jrip.2017.57

Scopus id: 85040733353

Review

An update on allopurinol and kidney failure; new trend for an old drug

Amirhesam Alirezaei 1, Hassan Argani 1 * , Masoumeh Asgharpour 2, Ayad Bahadorimonfared 3, Mahmood Bakhtiyari 4,5

1 Clinical Research and Development Center at Shahid Modarres Hospital, Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Nephrology, Rouhani Hospital of Medical Sciences, Babol, Iran
3 Department of Health & Community Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
5 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding author: Hassan Argani, Email: hassanargani@hotmail.com

Abstract

Allopurinol is an inhibitor of xanthine oxidase (XO) enzyme. This drug is a reducer of uric acid in the body and one of the golden drugs with worldwide administration. XO is an important biological source of free radical generation. Allopurinol as an antioxidant, has direct and indirect antioxidant activity on these free radicals such as hydroxyl radical and superoxide anion. The purpose of this paper is to determine the impact of allopurinol on some aspects of renal disturbances such as renal ischemia/reperfusion injury (IRI), nephrotoxicity and contrast-induced nephropathy (CIN).

Implication for health policy/practice/research/medical education:

Findings of this review show that treatment with allopurinol as a purine inhibitor of xanthine oxidase enzyme can decrease oxidative stress and uric acid levels and may help to restore the endothelial function and slow down the progression of renal disorder to end stage renal disease.

Please cite this paper as: Alirezaei A, Argani H, Asgharpour M, Bahadorimonfared A, Bakhtiyari M. An update on allopurinol and kidney failure; new trend for an old drug. J Renal Inj Prev. 2017;6(4):297-302. DOI: 10.15171/jrip.2017.57.  

First name
 
Last name
 
Email address
 
Comments
 
Security code