eISSN: 2345-2781  
Submitted: 29 Jul 2017

Accepted: 01 Nov 2017
First published online: 08 Dec 2017
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J Renal Inj Prev. 2018;7(2):69-72.
doi: 10.15171/jrip.2018.17

Scopus id: 85044779425

Brief Communication

High-salt intake during pregnancy may influence the outcome of renal ischemia/reperfusion in in adult offspring

Felora Shahzamani 1,2, Ramesh Monajemi, Mehdi Nematbakhsh 1,3,4 *

1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
3 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
4 IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran
*Corresponding author: Prof. Mehdi Nematbakhsh, Ph.D; Email: nematbakhsh@med.mui.ac.ir

Abstract

Introduction: The salt diet during the pregnancy may disturb the adult offspring’s organs functions.

Objectives: This study was designed to determine the role of high salt intake during pregnancy on the outcome of renal ischemia reperfusion (IR) in adult offspring.

Materials and Methods: Renal IR was induced in 55 adult male and female offspring from mothers who intake high salt or normal drinking water during pregnancy, and the kidney function was evaluated.

Results: Salt intake during pregnancy increased the serum levels of creatinine (Cr) and blood urea nitrogen (BUN) and decreased creatinine clearances (ClCr) level in offspring after renal IR gender dependently.

Conclusion: The structural change in kidney of offspring from mothers who were subjected to salt intake during pregnancy may influence the outcomes of offspring’s kidney functions after renal IR.

Implication for health policy/practice/research/medical education:

The structural change in kidney of offspring form mothers who were subjected to salt intake during pregnancy may influence the outcomes of offspring’s kidney functions after renal ischemia reperfusion (I/R).

Please cite this paper as: Shahzamani F, Monajemi R, Nematbakhsh M. High-salt intake during pregnancy may influence the outcome of renal ischemia/reperfusion in in adult offspring. J Renal Inj Prev. 2018;7(2):69-72. DOI: 10.15171/jrip.2018.17.

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