eISSN: 2345-2781  
J Renal Inj Prev. 2018;7(4):235-239.
doi: 10.15171/jrip.2018.54

Original

Evaluation of the antioxidant effects of zolpidem in the rat model of cisplatin-induced nephrotoxicity

Amin Hasanvand 1 * , Najmeh Pirzadroozbahani 2, Fariba Ahmadizar 3, Ali Kharazmkia 4, Samareh Mir 4, Peyman Amanolahi Baharvand 5, Mehdi Goudarzi 6, Reza Mohammadrezaei Khorramabadi 2

1 Department of Pharmacology and toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
4 Department of Pharmacotherapy, Faculty of pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
5 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
6 Medical Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding author: Amin Hasanvand, Ph.D, Emails: dr.hasanvand@yahoo.com, Email: AminHasanvand@lums.ac.ir

Abstract

Introduction: Nephrotoxicity is one of the most important side effects of cisplatin which has limited its use. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) plays a significant role in the pathogenesis of this drug.

Objectives: The aim of this study was to evaluate the antioxidant effect of zolpidem on the reduction of nephrotoxicity associated with cisplatin. Materials and Methods: In this study, 40 adult male rats were divided into 4 groups; 1) healthy group, 2) control group, 3, 4) cisplatin-induced nephrotoxicity + different doses of zolpidem. After a certain period of time, the urine, spinal cord and kidney samples of rats were collected. Then, urine levels of functional factors including urea, creatinine and albumin/ creatinine ratio, antioxidant enzymes and malondialdehyde (MDA) levels were estimated. Consequently, histological studies were conducted with the collected samples.

Results: Zolpidem reduced levels of urea, creatinine, albumin/creatinine ratio, and MDA. It also increased the amount of antioxidant enzymes of the kidney including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX), and moderated the tubular damage caused by the use of cisplatin.

Conclusion: Zolpidem is able to improve the nephrotoxicity by reducing oxidative stress.

Implication for health policy/practice/research/medical education:

Zolpidem is a nonspecific hypnotic drug that has antioxidant and neuroprotective properties. Cisplatin is mainly secreted through the kidneys, and its accumulation in tubular tuberculosis is more than 5 times greater than other tissues. Zolpidem exhibits this effect by reducing oxidative stress, increasing the activity of the antioxidant system, including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX), and preventing apoptosis in renal cells. The present study has approved, the antioxidant effect of zolpidem on the improvement of the defect of antioxidant system of the kidney in nephrotoxicity.

Please cite this paper as: Hasanvand A, Pirzadroozbahani N, Ahmadizar F, Kharazmkia A, Mir S, Amanolahi Baharvand P, et al. Evaluation of the antioxidant effects of zolpidem in the rat model of cisplatin-induced nephrotoxicity. J Renal Inj Prev. 2018;7(4):235-239. Doi: 10.15171/jrip.2018.54.

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