eISSN: 2345-2781  
Submitted: 07 Oct 2017

Accepted: 28 Mar 2018
First published online: 06 May 2018
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J Renal Inj Prev. 2018;7(4):297-300.
doi: 10.15171/jrip.2018.65

Original

Serum concentration of hs-CRP in obese individuals with and without metabolic syndrome and its association with parameters of metabolic syndrome

Mahmood Mirhoseini 1 * , Hamid Daemi 2, Mahshid Masoom Babaiee 3, Majid Asadi-Samani 4, Leilaassadat Mirhoseini 5, Morteza Sedehi 2

1 Shiraz University of Medical Sciences, Shiraz, Iran
2 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Students Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
5 Arak University of Medical Sciences, Arak, Iran
*Corresponding author: Mahmood Mirhoseini, Email: Email: seidmahmood_mirhoseini@yahoo.com

Abstract

Introduction: Serum level of high sensitivity C-reactive protein (hs-CRP), as an inflammatory marker, can play a role in development of metabolic syndrome in obese individuals.

Objectives: This study aimed to determine serum concentration of hs-CRP in obese patients with metabolic syndrome and determine the association of this factor with factors involved in the progression of metabolic syndrome.

Patients and Methods: In this study, samples were selected by convenient method from obese patients, admitted to Kashani and Hajar hospitals (Shahrekord, Iran). First, based on NCEP-ATPIIIdefined metabolic syndrome, parameters of metabolic syndrome and serum levels of vitamin D were measured and a questionnaire containing demographics was completed for each participant. Accordingly, the samples (n=192) were divided into two identical groups; obese individuals without metabolic syndrome (controls) and obese individuals with metabolic syndrome (case group). HsCRP levels were measured in both groups.

Results: Serum level of hs-CRP in the case group was 17.58±1.40 µg/mL and in the control group was 9.04±1.26 µg/mL, which was significantly higher in the case group than the control group (P<0.001). Serum concentration of hs-CRP in case and control subjects had a negative significant correlation with vitamin D (P<0.001), however, serum level of hs-CRP had no significant association with high density lipoprotein cholesterol (HDL-C), triglyceride (TG), fasting blood sugar (FBS), abdominal circumference, body mass index (BMI), and height (P>0.05).

Conclusion: Hs-CRP can be used for prognosis and early detection of patients at risk of metabolic syndrome.

Implication for health policy/practice/research/medical education:

Inflammatory markers can be considered as risk factors for the development of metabolic syndrome in obese subjects. The present study confirms the role of hs-CRP as an inflammatory marker in the progression of metabolic syndrome in obese patients and its association with vitamin D deficiency that can play a significant role in prevention and control of metabolic syndrome in obese individuals.

Please cite this paper as: Mirhoseini M, Daemi H, Masoom Babaiee M, Asadi-Samani M, Mirhoseini L, Sedehi M. Serum concentration of hs-CRP in obese individuals with and without metabolic syndrome and its association with parameters of metabolic syndrome. J Renal Inj Prev. 2018;7(4):297-300. DOI: 10.15171/jrip.2018.65.

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