eISSN: 2345-2781  
J Renal Inj Prev. 2019;8(1):1-5.
doi: 10.15171/jrip.2019.01

Review

The therapeutic effect of autologous bone marrow mesenchymal stem cells to prevent the progress of chronic allograft nephropathy

Farhad Gholami 1, Ali Ghasemi 2, Ahmad Reza Bahrami 3, Hamid Reza Bidkhouri 3, Hojat Naderi Mishkin 4, Masoud Pezeshki Rad 5, Farzaneh Sharifipour 6 *

1 Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Mazandaran, Iran
2 Department of Hematology and Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Biology, Faculty of Sciences, Ferdowsi University Of Mashhad, Mashhad, Iran 4
4 Academic Center for Education, Culture and Research (ACECR), Stem Cell and Regenerative Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5 Associate Professor of Radiology, Mashhad University of Medical Sciences, Mashhad, Iran 6
6 Division of Nephrology and Hypertension, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding author: Farzaneh Sharifipour, Email: Email: SharifipourF@mums.ac.ir

Abstract

Progenitor cells or mesenchymal stem cells are new cells, with renovation and regeneration ability and tissues repair. In recent years, administration of stem cells has been introduced to treat a variety of diseases including chronic allograft injury (CAI). It seems that stem cells can create a turning point in regenerative medicine through repair, replacement with damaged tissues or with their paracrine effects.

Implication for health policy/practice/research/medical education:

Mesenchymal non-hematopoietic stem cells are undifferentiated progenitor bone marrow with the ability of renewal and reconstruction and healing of injured tissues.

Please cite this paper as: Gholami F, Ghasemi A, Bahrami AR, Bidkhouri HR, Naderi Mishkin H, Pezeshki Rad M, et al. The therapeutic effect of autologous bone marrow mesenchymal stem cells to prevent the progress of chronic allograft nephropathy. J Renal Inj Prev. 2019;8(1):1-5. DOI: 10.15171/jrip.2019.01.

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