eISSN: 2345-2781  
Submitted: 10 Apr 2018

Accepted: 26 Jul 2018
First published online: 20 Aug 2018
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J Renal Inj Prev. 2019;8(1):6-10.
doi: 10.15171/jrip.2019.02

Original Article

An investigation of the efficacy on hepatitis B vaccination in hemodialysis patients in Ardabil, Iran

Susan Mohammadi Kebar 1 * , Saeed Hoseininia 1, Yousef Mohammadi Kebar 1, Mohammad Broumand 2

1 Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran 2
2 Ardabil University of Medical Sciences, Ardabil, Iran
*Corresponding author: Susan Mohammadi Kebar, Email: Email: s.mohammadikebar@gmail.com

Abstract

Introduction: Hemodialysis patients usually demonstrate lower immune response to hepatitis B vaccine compared to non-uremic population.

Objectives: The present study aimed to determine the level of response to hepatitis B vaccination in patients under hemodialysis.

Patients and Methods: This study was conducted on 172 live patients receiving hemodialysis in the dialysis department of Buali hospital in Ardabil, Iran (2015). To analyze their response to the vaccine, their vaccination titers were investigated. Before vaccination, the serological markers of hepatitis B and C were checked in all of the patients. Those for whom HBsAg and HBsAb results were negative and had not received the vaccinein the past entered the study. The patients received a double dose of hepatitis B vaccine at 0, 1, and 6 months after the beginning of dialysis. The response to the vaccine was investigated by measuring the level of patients’ hepatitis B antibody one month after receiving the last dose of the vaccine.

Results: Seventy patients (40% of the total) displayed a proper immune response to the vaccine, 34 patients (19.8%) were without, and 68 patients (39.5%) were identified to have poor response. The results of Pearson’s correlation test indicated that there is a negative correlation between the patients’ age and their response to the vaccine.

Conclusion: The results of this study indicated that higher age is one of the factors that reduce the effectiveness of hepatitis B vaccine in hemodialysis patients.

Implication for health policy/practice/research/medical education:

A study on 172 live patients receiving hemodialysis indicated that higher age is one of the factors that reduce the effectiveness of hepatitis B vaccine in hemodialysis patients.

Please cite this paper as: Mohammadi Kebar S, Hoseininia S, Mohammadi Kebar Y, Broumand M. An investigation of the efficacy on hepatitis B vaccination in hemodialysis patients in Ardabil, Iran. J Renal Inj Prev. 2019;8(1):6-10. DOI: 10.15171/jrip.2019.02.

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