eISSN: 2345-2781  
Submitted: 20 Oct 2017

Accepted: 24 Jan 2018
First published online: 26 Feb 2018
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J Renal Inj Prev. 2019;8(1):38-43.
doi: 10.15171/jrip.2019.08

Original

Study of antimicrobial effect of some plants of Lamiaceae family on Escherichia coli species isolated from children with urinary tract infection

Hossein Emad Momtaz 1, Shirin Moradkhan 2,3 * , Mohammad Yousef Alikhani 4, Farzaneh Esnaashari 5, Mojdeh Afkhami 1

1 Division of Pediatric Nephrology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2 Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5 Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding author: Shirin Moradkhani, Email: Email: shirin.moradkhani@yahoo.com

Abstract

Introduction: Urinary tract infection (UTI) has a high prevalence in children. It is an important cause of renal scar, chronic renal disease, failure to thrive and hypertension. The unnecessary consumption of antibiotics results in the bacterial resistance to most common drugs. In addition, possible drug allergic reaction and side effects should be considered. Therefore, finding new antimicrobial compounds is necessary.

Objectives: In this study, the antimicrobial effect of some plants of Lamiaceae family on Escherichia coli in comparison with common antibiotics used in UTI was investigated.

Materials and Methods: In this experimental study, the hydroalcoholic extract of 13 plant species from Lamiaceae family were prepared and their antimicrobial effects were assessed by the agar well diffusion method. In addition, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were investigated using the serial dilution method. The zone of inhibition (ZOI) of the growth of E. coli was compared between the studied extracts and five most common antibiotics in the treatment of UTI.

Results: The mean diameter of ZOI was significantly higher for amikacin than the studied extracts and other antibiotics. Among the herbal extracts, the highest ZOI was observed for Nepeta crispa. In addition, the MIC and MBC of N. crispa were significantly lower than other extracts.

Conclusion: According to the side effects and relatively high cost of chemical and synthetic drugs, use of herbal extracts, such as N. crispa may be recommended as an alternative treatment of UTI with E. coli. The results of present study are promising to introduce new candidates in the treatment of UTI.

Implication for health policy/practice/research/medical education:

Considering high prevalence of urinary tract infection (UTI) in children and its important complications, finding new natural treatments with fewer side effects and lower microbial resistance than usual antibiotics may be valuable. In this study authors tried to show the antimicrobial effect of some herbal extracts against E. coli for possible use of those as complementary treatment of UTI.

Please cite this paper as: Momtaz HE, Moradkhani Sh, Alikhani MY, Esnaashari F, Afkhami M. Study of antimicrobial effect of some plants of Lamiaceae family on Escherichia coli species isolated from children with urinary tract infection. J Renal Inj Prev. 2019;8(1):38-43. Doi: 10.15171/jrip.2019.09.

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