eISSN: 2345-2781  
Submitted: 09 May 2017

Accepted: 01 Sep 2018
First published online: 06 Sep 2018
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J Renal Inj Prev. 2019;8(1):54-61.
doi: 10.15171/jrip.2019.11


Metformin and its anti-inflammatory and anti-oxidative effects; new concepts

Ali Hasanpour Dehkordi 1, Abolfazl Abbaszadeh 2, Samareh Mir 3, Amin Hasanvand 4 *

1 Department of Medical-Surgical, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Pharmacotherapy, Faculty of pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
4 Nutritional Health Research Center, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
*Corresponding author: Amin Hasanvand, PhD; Email: Email: dr.hasanvand@yahoo.com


Metformin is one of the oldest and commonly used blood sugar lowering drugs, having limited side effects and used as the first line treatment in patients suffering from diabetes mellitus. Moreover, various studies have emphasized on the anti-inflammatory and antioxidant role of metformin, with multiple mechanisms, which activation of AMPK by metformin has had a key role in many of them. During the searches on the internet websites of PubMed, Elsevier, Google Scholar, and Science Direct, 76 papers related to the anti-inflammatory and antioxidant role of metformin were selected and reviewed since 2003 to 2017. At the cellular level, metformin suppresses the inflammation in many cases and reduces or eliminates inflammatory factors mainly through dependent mechanisms and sometimes independent of AMPK at the cellular level and through other ways at the systematic levels. It is also effective in reducing the level of oxidative stress factors by regulating the antioxidant system of the cell. All evidence suggests the antioxidant and anti-inflammatory role of metformin in various conditions. Metformin can be an appropriate treatment option for many diseases, which inflammatory processes and oxidative stress play a role in their pathogenesis.

Implication for health policy/practice/research/medical education:

Metformin, with the chemical name of 1,1-dimethylbiguanide hydrochloride, is in the first line of treatment of patients with type 2 diabetes. Metformin treatment reduced inflammatory markers such as IL-1β, iNOS, and TNF-α, and reduced the number of microglia cells, and accordingly, it inhibited the inflammatory response. It was indicated that metformin reduced levels of ROS and NO and increased the antioxidant system, such as SOD.

Please cite this paper as: Hasanpour Dehkordi A, Abbaszadeh A, Mir S, Hasanvand A. Metformin and its anti-inflammatory and anti-oxidative effects; new concepts. J Renal Inj Prev. 2019;8(1):54-61. DOI: 10.15171/jrip.2019.11.

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