Revised: 28 Jan 2013
First published online: 01 Sep 2013
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J Renal Inj Prev. 2013;2(3).
doi: 10.12861/jrip.2013.30
PMID: 25340139
PMCID: PMC4206023
  Abstract View: 1043
  PDF Download: 555

Short Communication

Impact of inflammation on anemia of hemodialysis patients who were under treatment of recombinant human erythropoietin

Mahmoud Rafiean-Kopaie 1 * , Hamid Nasri 2

1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Prof. Mahmoud Rafieian-Kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. Email: rafieian@yahoo.com

Article

The aim of this study was to investigate the association between serum C-reactive protein (CRP) as the marker of inflammation with serum ferritin level and its role in the severity of anemia of hemodialysis (HD) patients. A cross-sectional study was conducted on a group of stable hemodialysis patients. There were 36 patients overall, 25 of which were non-diabetic and 11 were diabetic mean patients’ age was 53 (±15.8) years. In this study, there was a significant inverse correlation between serum ferritin and hematocrit level (r=-0.34, p=0.044) (adjusted for age). Also a significant positive correlation between serum CRP and serum iron (r=0.44, p=0.008) (adjusted for age too) was observed. Moreover, in male HD patients, a significant positive correlation between serum CRP and serum ferritin (r=0.56, p=0.009) was found. Malnutrition and inflammation in hemodialysis may increase serum ferritin concentration apart from iron status, and needs more attention during iron therapy for the treatment of anemia in HD patients.
Implication for health policy/practice/research/medical education:
Malnutrition-inflammation complex syndrome, may increase serum ferritin concentration apart from iron status, and needs more attention during iron therapy for the treatment of anemia in regular hemodialysis patients.

Please cite this paper as: Rafiean-Kopaie M, Nasri H. Impact of inflammation on anemia of hemodialysis patients who were under treatment of recombinant human erythropoietin. J Ren Inj Prev 2013; 2(3): 93-95.
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