J Renal Inj Prev. 2015;4(2).
doi: 10.12861/jrip.2015.10
PMID: 26060837
PMCID: PMC4459728
  Abstract View: 1241
  PDF Download: 776

Original Article

Protective effect of pomegranate flower extract against gentamicin-induced renal toxicity in male rats

Ferdos Sadeghi 1,2, Mehdi Nematbakhsh 1,3,4 * , Ali Noori-Diziche 2, Fatemeh Eshraghi-Jazi 1, Ardeshir Talebi 5, Hamid Nasri 1, Azam Mansouri 1, Aghdas Dehghani 1, Shadan Saberi 1, Soheila Shirdavani 1, Farzaneh Ashrafi 6

1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
3 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
4 Isfahan MN Institute of Basic and Applied Sciences Research Center, Isfahan, Iran
5 Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
6 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding author: Prof. Mehdi Nematbakhsh, Email: nematbakhsh@med.mui.ac.ir

Article

Introduction: Gentamicin (GM) as an antibiotic is used in clinic. However, its administration is limited by side effects such as nephrotoxicity. Herbal extracts could be used in therapeutic approaches.

Objectives: The present study was planned to investigate whether pomegranate flower extract (PFE) could ameliorate GM-induced renal toxicity in male rats.

Materials and Methods: Twenty eight male Wistar rats were divided into 5 groups. Groups 1 and 2 respectively received PFE 25 and 50 mg/kg for 9 days. Groups 3, 4 and 5 received saline, PFE 25 mg/kg, and PFE 50 mg/kg for 9 days, respectively, and GM (100 mg/kg/day) was administered from day 3 on. Blood samples were obtained, and after sacrificing the animals, the kidneys were removed for histopathology investigations.

Results: GM alone increased the serum levels of creatinine (Cr) and blood urea nitrogen (BUN), and tissue damage and kidney weight (P < 0.05). However, administration of low dose of PFE accompanied with GM decreased these markers significantly (P < 0.05). Low dose of PFE also ameliorated weight loss induced by GM (P < 0.05).

Conclusion: It is concluded that PFE 25 mg/kg is the effective dose to ameliorate nephrotoxicity induced by GM.

Implication for health policy/practice/research/medical education:

Pomegranate flower extract (PFE) may has protective role and ameliorate impact on nephrotoxicity induced by gentamicin.

Please cite this paper as: Sadeghi F, Nematbakhsh M, Noori-diziche A, Eshraghi-Jazi F, Talebi A, Nasri H, et al. Protective effect of pomegranate flower extract against gentamicin-induced renal toxicity in male rats. J Renal Inj Prev. 2015; 4(2): 45-50. DOI: 10.12861/jrip.2015.1

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