First published online: 24 Apr 2015
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J Renal Inj Prev. 2016;5(1).
doi: 10.15171/jrip.2016.03
PMID: 27069959
PMCID: PMC4827379
  Abstract View: 1139
  PDF Download: 611

Original Article

BK virus nephropathy is not always alone

Haydarali Esmaili 1, Elmira Mostafidi 1,2, Mohammadreza Ardalan 2 * , Amir Vahedi 1,2, Fariba Mahmoodpoor 2, Mohammadali Mohajel-Shoja 3

1 Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
2 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Pediatric Neurosurgery Unit, University of Alabama, Alabama, USA
*Corresponding author: Mohammadreza Ardalan, Email: ardalan34@yahoo.com

Article

Introduction: BK virus associated allograft nephropathy (BKVAN) is an important cause of allograft lost that often occurs in the first year of transplantation. The state of over immunosuppression also predispose these patients to various opportunistic viral infection

Objectives: This research aimed to study the renal transplanted patients for BK viremia and BKVAN. Patients and methods: This observational study was conducted between January 2013 to December 2014 to study the renal transplanted patients for BK viremia and BKVAN. In our center patients received combination of de-sensitization therapy including antithymocyte globulin (ATG), rituximab (RITU), basiliximab, therapeutic plasma exchange, and methylprednisolone (MTP), in high risks or only MTP therapy in immunologically low risk patients.

Results: Of total number of 26 patients (20-52 years, M/F 17/9), seven patients received ATG and seven patient received intensive desensitizing protocols, BKVAN and BK viremia happened in three and two patients in above groups subsequently, only one patient developed BKVAN in low risk group. We also observed; cytomegalovirus (CMV) and parvovirus B19 infection and hemophagocytic syndrome (HPS), thrombotic microangiopathy (TMA) and endocarditis in our patients with BKVAN and BK viremia.

Conclusion: Awareness about the possibility of BK virus nephropathy and appropriate immunosuppression minimization are crucial components of management. Consideration of other opportunistic infections and specific syndromes are also very important.

Implication for health policy/practice/research/medical education:

Awareness about the possibility of BK virus nephropathy and appropriate immunosuppression minimization are crucial components of management of renal transplanted patients. Consideration of other opportunistic infections and specific syndromes are also very important.

Please cite this paper as: Esmaili H, Mostafidi E, Ardalan M, Vahedi A, Mahmoodpoor F, Mohajel-Shoja M. BK virus nephropathy is not always alone. J Renal Inj Prev. 2016;5(1):12-16. DOI: 10.15171/jrip.2016.03

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