First published online: 28 Feb 2016
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J Renal Inj Prev. 2016;5(1).
doi: 10.15171/jrip.2016.07
PMID: 27069965
PMCID: PMC4827383
  Abstract View: 1263
  PDF Download: 803

Original Article

Role of S-methylisothiourea (SMT) in renal ischemia/reperfusion injury in rats

Fatemeh Kanani 1, Faezeh Fazelnia 1, Mohaddeseh Mojarradfard 1, Mehdi Nematbakhsh 1,2,3 * , Fatemeh Moslemi 1, Fatemeh Eshraghi-Jazi 1, Ardeshir Talebi 4

1 Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Isfahan MN Institute of Basic & Applied Sciences Research, Isfahan, Iran
4 Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding author: Prof. Mehdi Nematbakhsh, Email: nematbakhsh@med.mui.ac.ir

Article

Introduction: Excessive production of nitric oxide (NO) via inducible nitric oxide synthase (iNOS) is associated in renal ischemia reperfusion injury (IRI).

Objectives: This study was designed to investigate the role of S-methylisothiourea (SMT) as selective inhibitor iNOS in renal IRI. Materials and Methods: Male Wistar rats were subjected to 45 minutes of bilateral renal ischemia by occlusion of renal vessels of both kidney followed by 24 hours of reperfusion. Prior to renal IRI, the rats received either vehicle (saline, group 2) or SMT (50 mg/kg, group 3), and were compared with the sham-operated animals (group 1). At the end of reperfusion period, the rats were sacrificed for kidney tissue pathology investigation.

Results: Serum creatinine (Cr), blood urea nitrogen (BUN), nitrite levels, and kidney weight significantly increased in groups 2 and 3 (P < 0.05). Kidney tissue damage scores in groups 2 and 3 were also higher than that in the sham-operated group (P < 0.05).

Conclusion: SMT not only prevent the kidney during IRI, but also promotes kidney function disturbance and severity of renal injury.

Implication for health policy/practice/research/medical education:

In an experimental investigation on rats, we found, S-methylisothiourea not only prevent the kidney during ischemia/reperfusion injury, but also promotes kidney function disturbance and severity of renal injury.

Please cite this paper as: Kanani F, Fazelnia F, Mojarradfard M, Nematbakhsh M, Moslemi F, Eshraghi-Jazi F, Talebi A. Role of S-methylisothiourea (SMT) in renal ischemia/ reperfusion injury in rats. J Renal Inj Prev. 2016;5(1):29-33. DOI: 10.15171/jrip.2016.07

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