Logo-jrip
ePublished: 16 May 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Renal Inj Prev. 2016;5(2): 85-88.
doi: 10.15171/jrip.2016.18
PMID: 27471740
PMCID: PMC4962675
  Abstract View: 4203
  PDF Download: 2048

Original Article

The effect of cytomegalovirus infection on acute rejection in kidney transplanted patients  

Boshra Hasanzamani*, Maryam Hami, Vajihe Zolfaghari, Mahtab Torkamani, Mahin Ghorban Sabagh, Saiideh Ahmadi Simab

1 Kidney Transplantation Complications Research Center, Montaserie Organ Transplantation Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding Author: *Corresponding author: Boshra Hasanzamani, , Email: hasanzamanib@mums.ac.ir

Abstract

Introduction: It is known that cytomegalovirus (CMV) infection is a common problem among kidney transplant patients. This infection can be increased morbidity and decreased graft survival. This problem has been associated with acute rejection too.

Patients and Methods: One hundred and thirty renal transplant patients were included in a prospective, case-control study. The renal transplant patients were divided into two groups; patients group with CMV infection and control group without CMV infection. Serum CMV-IgG in all patients was positive (donor and recipients). None of patients had received anti-thymocyte-globulin and thymoglobulin. CMV infection was diagnosed by quantitative CMV-PCR (polymerase chain reaction) test (more than 500 copies/μg). Rejection episode was defined by kidney isotope scan or biopsy.

Results: In the group of 66 CMV infection patients (41 male [62.1%] and 25 female [37.9%]) the incidence of graft rejection was 36%, however in the group of 64 control patients the incidence of graft rejection was 9.4 % (P < 0.005).

Conclusion: CMV infection is important predisposing factor for acute allograft rejection after kidney transplantation. The results of this study suggests that the control of CMV infection could decrease episodes of acute kidney rejection.

 

Implication for health policy/practice/research/medical education:

Awareness about the relationship between cytomegalovirus (CMV) infection and acute renal rejection is very important. Early diagnose of CMV infection can reduce episodes of acute renal rejection.

Please cite this paper as: Hasanzamani B, Hami M, Zolfaghari V, Torkamani M, Ghorban Sabagh M, Ahmadi Simab S. The effect of cytomegalovirus infection on acute rejection in kidney transplanted patients. J Renal Inj Prev. 2016;5(2):85-88. DOI: 10.15171/jrip.2016.18.

 
 
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 4204

Your browser does not support the canvas element.


PDF Download: 2048

Your browser does not support the canvas element.