J Renal Inj Prev. 2016;5(3).
doi: 10.15171/jrip.2016.29
PMID: 27689110
PMCID: PMC5040000
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Original Article

Effect of angiotensin II type 1 receptor blockade on kidney ischemia/reperfusion; a gender-related difference

Fatemeh Moslemi 1, Pegah Taheri 1, Mahdis Azimipoor 1, Sina Ramtin 1, Mostafa Hashemianfar 1, Ali Momeni- Ashjerdi 1, Fatemeh Eshraghi-Jazi 1, Ardeshir Talebi 1, Hamid Nasri 1, Mehdi Nematbakhsh 1,2,3 *

1 Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
3 IsfahanMN Institute of Basic & Applied Sciences Research, Isfahan Iran
*Corresponding author: Professor Mehdi Nematbakhsh, Ph.D, Email: nematbakhsh@med.mui.ac.ir

Article

Background: Renal ischemia/reperfusion (I/R) injury may be related to activity of reninangiotensin system (RAS), which is gender-related. In this study, it was attempted to compare the effect of angiotensin II (Ang II) receptor type 1 (AT1R) blockade; losartan in I/R injury in male and female rats.

Materials and Methods: Male and female Wistar rats were assigned as sham surgery, control I/R groups treated with vehicle, and case I/R groups treated with losartan (30 mg/kg). Vehicle and losartan were given 2 hours before bilateral kidney ischemia induced by clamping renal arteries for 45 minutes followed by 24 hours of renal reperfusion.

Results: The I/R injury significantly increased the serum levels of blood urea nitrogen (BUN) and creatinine (Cr), and kidney tissue damage score in both genders. However, losartan decreased these values in female rats significantly (P < 0.05). This was not observed in male rats.

Conclusion: Losartan protects the kidney from I/R injury in female but not in male rats possibly because of gender-related difference of RAS.

Implication for health policy/practice/research/medical education:

Losartan acts differently in ischemia/reperfusion injury in male and female.

Please cite this paper as: Moslemi F, Taheri P, Azimipoor M, Ramtin S, Hashemianfar M, Momeni-Ashjerdi A, et al. Effect of angiotensin II type 1 receptor blockade on kidney ischemia/reperfusion; a gender-related difference. J Renal Inj Prev. 2016;5(3):140-143. DOI: 10.15171/jrip.2016.29

 

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