Fatemeh Yaghoubi
1, Maliheh Yarmohammadi
2*, Mohammad Vasei
31 Nephrology Research Center and Department of Nephrology, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Nephrology, Semnan University of Medical Sciences, Semnan, Iran
3 Department of Pathology and Laboratory Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract
We report a 55-year-old man presented with anemia and weakness, history of flank pain, hematuria and nephrotic syndrome. Spiral abdominopelvic computerized tomography (CT) scan showed multiloculated cystic mass (120 ×100 ×80 mm) in lower portion of left kidney with internal enhancing solid components and coarse peripheral calcifications. Radical nephrectomy of left kidney was done and biopsy confirmed renal cell carcinoma (RCC), papillary type, sarcomatoid foci, Fuhrman grade III. We assumed that, presence of nephrotic syndrome and paraneoplastic glomerulopathy leaded to heavy proteinuria in this case. Secondary, paraneoplastic glomerulopathy such as immunoglobulin A nephropathy and focal segmental glomerulosclerosis as a paraneoplastic syndrome of RCC have been reported previously. RCC can present with a wide range of signs and symptoms. Atypical presentations of papillary RCC such as proteinuria should be considered for patients presenting with nephrotic syndrome.
Implication for health policy/practice/research/medical education:
We report a 55-year-old man presented with anemia and weakness, history of flank pain, hematuria and nephrotic syndrome. Spiral abdominopelvic computerized tomography (CT) scan showed multiloculated cystic mass (120 ×100 ×80 mm) in lower portion of left kidney with internal enhancing solid components and coarse peripheral calcifications. This case report implicated that proteinuria should be considered as an atypical presentations of renal cell carcinoma (RCC).
Please cite this paper as: Yaghoobi F, Yarmohammadi M. Vasei M. Paraneoplastic proteinuria in papillary renal cell carcinoma; a case report. J Renal Inj Prev. 2016;5(4):207-209. DOI: 10.15171/jrip.2016.44