First published online: 04 Apr 2017
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J Renal Inj Prev. 2017;6(3):231-235.
doi: 10.15171/jrip.2017.43

Scopus id: 85039937131
  Abstract View: 1463
  PDF Download: 1017

Original Article

Urinary level of interleukin-1alpha and interleukin-6 in patients underwent extracorporeal shock wave lithotripsy

Mohsen Rajabnia Chenari 1, Faramarz Fazeli 2 * , Mehdi Jahantigh 3, Javid Dehghan 4, Amin Zarghami 5, Mohammad Bahadoram 6,7, Ali Ghorbani 6, Sajedeh Mirshahvalad 8

1 Department of Internal Medicine, Kurdistan University of Medical Sciences, Kurdistan, Iran
2 Department of Urology, Zahedan University of Medical Sciences, Zahedan, Iran
3 Department of Pathology, Zahedan University of Medical Sciences, Zahedan, Iran
4 Department of Community Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
5 Iranshahr University of Medical Sciences, Iranshahr, Iran
6 Chronic Renal Failure Research Center, Department of Internal Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7 Student Research Committee, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
8 Student Research Committee, Babol University of Medical Sciences, Babol, Iran
*Corresponding author: Dr. Faramarz Fazeli, Email: fazeli88@yahoo.com

Article

Introduction: Extracorporeal shock wave lithotripsy (ESWL) was established as a dramatic procedure in the treatment of urinary stones. According to the growing utilization of ESWL as a major method of urinary stone, management and the reports have been reported based on renal tissue damage.

Objectives: We decided to examine the severity of ESWL-induced renal tissue damage and its related factors by monitoring the urinary levels of cytokines.

Patients and Methods: In this study, the urinary samples of 32 patients with urolithiasis were taken before, 24 hours and 14 days after ESWL and interleukin-1ɑ (IL-1a) and interleukin-6 (IL-6) levels were measured by enzyme-linked immunosorbent assay (ELISA) method.

Results: Our findings indicated that there was a significant difference between the urinary levels of both IL-1ɑ and IL-6 in 14 days before and after ESWL.

Conclusion: According to our results, ESWL leads to an inflammatory process in the urinary tract and the inflammation have continuously increased up to 14 days after procedure.

Implication for health policy/practice/research/medical education:

Findings of the current study highlighted the underlying inflammatory process following extracorporeal shock wave lithotripsy (ESWL) procedure and can be a good sample for further investigations.

Please cite this paper as: Rajabnia Chenari M, Fazeli F, Jahantigh M, Dehghan J, Zarghami A, Bahadoram M, et al. Urinary level of interleukin-1alpha and interleukin-6 in patients underwent extracorporeal shock wave lithotripsy. J Renal Inj Prev. 2017;6(3):231-235. DOI: 10.15171/jrip.2017.43.

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