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ePublished: 08 Jun 2017
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J Renal Inj Prev. 2017;6(4): 240-243.
doi: 10.15171/jrip.2017.45

Scopus ID: 85040716769
  Abstract View: 1929
  PDF Download: 1213

Original Article

Association between vitamin D, parathyroid hormone and inflammatory markers in urolithiasis patients

Shakila Venkatesan 1, Kalyani Chakkarai 1, Subramaniam Arulvijayavani 1,2, Gandhipuram Periyasamy Senthilkumar 1, Ramanitharan Manikandan 3, Muruganandham Kalyaperumal 3,4

1 Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
2 Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
3 Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
4 Department of Urology, Global hospital, Chennai, India

Abstract

Introduction: Hypercalciuria plays an important role in the pathogenesis of renal calculi. The role of vitamin D, parathyroid hormone (PTH), inflammatory markers highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in the development of renal calculi has not well defined.

Objectives: To assess the serum levels of vitamin D, PTH, hs-CRP and IL-6, urinary and serum calcium and phosphorus levels in patients with renal calculi and to compare these parameters with healthy controls

Patients and methods: It was a cross-sectional study. About 41 confirmed renal calculi patients and 41 age and sex matched controls were recruited. Patients with malignancies, hyperparathyroidism, chronic disease, and patients taking vitamin D supplementations were excluded. Serum levels of 25(OH) vitamin D, i-PTH, hs-CRP, IL-6, calcium and phosphorous, 24 hours urine levels of calcium and phosphorus were estimated

Results: There was a statistical significant difference in the serum levels of 25(OH) vitamin D (12.26 vs 19.61 ng/mL), i-PTH (75.5 vs. 33.5 pg/mL), hsCRP (5117.05 vs. 1721.87 ng/mL), IL-6 (13.49 vs. 1.47 pg/mL) calcium (11.5 vs. 9.4 mg/dL) and urinary calcium (370.5 vs. 342 mg/d) and phosphorous levels (1172 vs. 1432 mg/d) between the cases and the control. There was negative correlation between the levels of i-PTH and vitamin D (r = - 0.765) and positive correlation between i-PTH and hsCRP, IL-6, Serum calcium and urine calcium (r = 0.353, 0.340, 0.522, 0.501 respectively)

Conclusion: There was vitamin D inadequacy and increased levels of PTH, IL-6 and C-reactive protein, calcium in patients with renal calculi when compared with healthy controls.

Keywords: Urolithiasis, Vitamin D, Parathyroid hormone, Interleukin-6, Highly sensitive C-reactive protein

Implication for health policy/practice/research/medical education:

As urolithiasis patients are at a constant inflammatory insult caused by the calculi, the levels of inflammatory markers can be used to monitor the success of treatment. Vitamin D and anti-inflammatory agents may be used in the management of nephrolithiasis patients.

Please cite this paper as: Venkatesan S, Chakkarai K, Arulvijayavani S, Senthilkumar GP, Manikandan R, Kalyaperumal M. Association between vitamin D, parathyroid hormone and inflammatory markers in urolithiasis patients. J Renal Inj Prev. 2017;6(4):240-243. DOI: 10.15171/jrip.2017.45.

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