ePublished: 04 Aug 2017
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J Renal Inj Prev. 2017;6(4): 286-288.
doi: 10.15171/jrip.2017.54

Scopus ID: 85040735454
  Abstract View: 2470
  PDF Download: 2096

Case Report

Fenugreek (Trigonella foenum-graecum) induced interstitial nephritis

Sepideh Zununi-Vahed 1, Mohammadreza Ardalan 1 * , Fariba Mahmoodpoor 1, Kasra Ardalan 2, Ramin Tolouian 3

1 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Turkish Republic of North Cyprus
3 Division of Nephrology and Hypertension, University of Central Florida, college of medicine, Orlando, FL, USA
*Corresponding author: Prof. Mohammadreza Ardalan, ardalan34@yahoo.com


Herbal medicine has grabbed the public interest and there is a general belief of their safety and life compatibility. There are growing proportion of reported side effects of herbal medicine in past years. We reported a 62-year-old woman who developed acute interstitial nephritis (AIN) accompanied by autoimmune hemolytic anemia (AIHA), three weeks after daily ingestion of heat extract of fenugreek. The patient’s renal, hematologic and liver panels were improved after steroid pulse therapy and fenugreek discontinuation. Fenugreek contains high amount of flavonoid which might be a main culprit for AIN and AIHA.
Keywords: Herbal, Fenugreek, Interstitial nephritis, Hemolytic anemia, Acute interstitial nephritis

Implication for health policy/practice/research/medical education:

Fenugreek (Trigonella foenum-graecum) contains high amount of flavonoid which might be a main culprit for AIN and AIHA.

Please cite this paper as: Zununi-Vahed S, Ardalan MR, Mahmoodpoor FM, Ardalan K و Tolouian R. Fenugreek (Trigonella foenum-graecum) induced interstitial nephritis. J Renal Inj Prev. 2017;6(4):286-288. DOI: 10.15171/jrip.2017.54.





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