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Submitted: 10 May 2019
Accepted: 03 Aug 2019
ePublished: 14 Sep 2019
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J Renal Inj Prev. 2019;8(4): 263-270.
doi: 10.15171/jrip.2019.50
  Abstract View: 344
  PDF Download: 200

Review

Surveying the relationship between Gly1057Asp polymorphism of IRS-2 gene and susceptibility to type 2 diabetes; a systematic review and meta-analysis study

Faezeh Kiani 1 ORCID logo, Fatemeh Sayehmiri 2 ORCID logo, Ali Hasanpour Dehkordi 3 ORCID logo, Morteza Motedayen 4 * ORCID logo

1 Research Center for Prevention of Psychosocial Impairment, Ilam University of Medical Sciences, Ilam, Iran
2 Student Research Committee, Proteomics Research Center, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
3 Social Determinants of Health Research Center, School of allied medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Cardiology Department, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
*Corresponding author: Morteza Motedayen, Emails: mor.mot2@gmail.com, mor.mot2@ZUMS.com

Abstract

Type 2 diabetes mellitus (T2DM) is a multi-factorial disease in which influenced by several genetic and environmental factors. Insulin receptor substrate 2 (IRS 2) is the main mediator of insulin in the liver which controls insulin sensitivity. Gly1057Asp polymorphism is one of the candidates to increase risk of T2DM. The present study is an attempt to study the relationship of Gly1057Asp polymorphism of IRS-2 and T2DM by a meta-analysis. A systemic search was conducted in English and Persian databases such as Scopus, PubMed, Google Scholar, SID, and other academic databases for studies that have investigated the relationship of Gly1057Asp polymorphism of IRS-2 and T2DM. This association was determined using odds ratios (ORs) with a confidence interval of 95% (CIs). Heterogeneity of the studies was examined by I2 index. Funnel plots and Egger tests were used to determine bias or publication bias. The collected data was analyzed in STATA through meta-analysis. Nine articles were selected as eligible for further analysis, which represented 3,196 patients with T2DM and 3409 controls subjects without T2DM. The present meta-analysis showed a significant relationship between GA genotype of Gly1057Asp polymorphism and T2DM (OR=0.88; 95% confidence interval, 0.79-0.98), whereas no significant relationship between GG and AA genotype with T2DM was seen; OR for GG and AA genotypes were 1.10 (95% CI, 0.99 -1.22) and 1.13 (95% CI, 0.95- 1.33), respectively. The results of our study show that genotype GA of Gly1057Asp polymorphism of IRS-2 gene plays a protective role and may decrease the risk of T2DM, whereas GG and AA genotypes are considered as a risk factor and related to development of T2DM to some extents. 
Keywords: Type 2 diabetes mellitus, Gly1057Asp polymorphism, Meta-analysis

Implication for health policy/practice/research/medical education:

The present meta-analysis showed a significant relationship between GA genotype of Gly1057Asp polymorphism and type 2 diabetes mellitus (OR=0.88; 95% confidence interval, 0.79-0.98), whereas no significant relationship between GG and AA genotype with type 2 diabetes mellitus was seen; OR for GG and AA genotypes were 1.10 (95% CI, 0.99 -1.22) and 1.13 (95% CI, 0.95-1.33), respectively.

Please cite this paper as: Kiani F, Sayehmiri F, Hasanpour Dehkordi A, Motedayen M. Surveying the relationship between Gly1057Asp polymorphism of IRS-2 gene and susceptibility to type 2 diabetes; a systematic review and meta-analysis study. J Renal Inj Prev. 2019;8(4):263-270. DOI: 10.15171/jrip.2019.50.

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