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Submitted: 23 Oct 2019
Accepted: 21 Apr 2020
ePublished: 29 May 2020
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J Renal Inj Prev. 2021;10(3): e20.
doi: 10.34172/jrip.2021.20
  Abstract View: 44
  PDF Download: 31

Original

Plasma N-terminal pro-brain natriuretic peptide level as a marker of adverse outcome in patients with co-existing diabetes, chronic kidney disease and heart failure

Amin Roshdy Soliman 1 ORCID logo, Rabab Mahmoud Ahmed 1 * ORCID logo, Ahmad Yousry 2, Tarek Samy Abdelaziz 1 * ORCID logo, Abdel Hakem Selem 2

1 Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of cardiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Tarek Samy Abdelaziz, Email: Tarek. samy80@yahoo.com

Abstract

Introduction: N-terminal pro–B-type natriuretic peptide (NT-proBNP) is a novel marker of cardiac disease and heart failure; both are in patients with diabetes and chronic kidney disease.

Objectives: This study aimed to investigate the NT-proBNP and adverse outcome in patients with diabetes complicated by chronic kidney disease (CKD).

Patients and Methods: We measured the serum levels of NT-proBNP. The association of this novel marker with re-hospitalization and mortality rate were prospectively compared among the studied groups.

Results: Among 120 patients, baseline NT-proBNP at the time of admission was significantly elevated in patients with CKD (P= 0.001). Levels of NT-proBNP were significantly elevated in patients with diabetes and CKD than those with CKD alone (P= 0.04) at the end of follow-up. Higher proBNP levels significantly correlated with decreased glomerular filtration rate (GFR) and higher serum creatinine levels (P= 0.03, P< 0.001, respectively). In addition, increased mortality was noticed in those patients.

Conclusion: NT-proBNP levels have prognostic implication in the setting of CKD, diabetes mellitus and heart failure. Adverse outcomes are; a higher rate of need for dialysis, re-hospitalization and increased mortality which are correlated with levels of NT-proBNP.


Keywords: NT-pro-BNP, Chronic kidney disease, Diabetes mellitus, Heart failure, Glomerular filtration rate

Implication for health policy/practice/research/medical education:

Measuring N-terminal pro–B-type natriuretic peptide (NT-proBNP) level in patients with coexisting chronic kidney disease, diabetes and heart failure may predict the risk of adverse outcomes consisting, the need for dialysis, re-hospitalization and mortality.

Please cite this paper as: Soliman AR, Ahmed RM, Yousry A, Abdelaziz TS, Selem AH. Plasma N-terminal pro-brain natriuretic peptide level as a marker of adverse outcome in patients with co-existing diabetes, chronic kidney disease and heart failure. J Renal Inj Prev. 2021; 10(3): e20. doi: 10.34172/jrip.2021.20.


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