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Submitted: 07 Dec 2019
Accepted: 27 Jan 2020
ePublished: 10 Mar 2020
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J Renal Inj Prev. 2021;10(1): e05.
doi: 10.34172/jrip.2021.05
  Abstract View: 76
  PDF Download: 31

Original Article

Association between serum insulin like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 levels and chronic kidney disease in diabetic patients

Volha N. Vasilkova 1 * ORCID logo, Tatsiana V. Mokhort 2 ORCID logo, Ivan Y. Pchelin 3 ORCID logo, Valentina K. Bayrasheva 4 ORCID logo, Elena P. Naumenko 5, Ludmila E. Korotaeva 5, Natallia A. Filiptsova 5

1 Department of Internal Medicine №1, Gomel State Medical University, Gomel, Belarus
2 Endocrinology Department, Belarusian State Medical University, Minsk, Belarus
3 Department of Faculty Therapy, Saint Petersburg State University, Saint Petersburg, Russia
4 Institute of Endocrinology, Almazov National Medical Research Centre, Saint Petersburg, Russia
5 Laboratory Department, Republican Research Centre for Radiation Medicine and Human Ecology, Gomel, Belarus

Abstract

Introduction: Insulin-like growth factor-1 (IGF-1) is a potent mitogen for glomerular mesangial cells which can stimulate cell migration and the production of fibronectin, proteoglycan, and type IV collagen, thereby promoting the development of the chronic kidney disease (CKD) in patients with diabetes.

Objectives: The aim of the study was to assess the associations between serum levels of IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3) and CKD in diabetic patients.

Patients and Methods: We investigated 102 Belarusian men and women with diabetes type 2 aged 56.67±0.81 years. Control group included 68 healthy people the same age. We estimated GFR with the use of the CKD-EPI creatinine-cystatin C equation to determine eGFRcr_cys. Serum total IGF-1 and IGFBP-3 levels were measured using immunoradiometric assay (IRMA) (Beckman Coulter, Czech Republic s.r.o.).

Results: Patients with diabetes had significantly lower level of IGF-1 than controls. However, IGFBP-3 levels were similar in the two groups. Diabetic patients with CKD had significantly higher levels of IGF-1 and IGFBP-3 than diabetic patients without CKD (P=0.0031). However, according to multivariate analysis, only IGF-1 and cystatin C were associated with renal impairment. In detail, the odds of having eGFR<60 mL/min/1.73 m2 increased with rising IGF-1 levels (OR: 1.025, [CI 1.002-1.048]).

Conclusion: Our study revealed that higher serum IGF-1 levels were positively associated with CKD in patients with diabetes. We suggest that IGF-1 might be a predictor of CKD in patients with diabetes. Further research is necessary to confirm the observed this association and to detect the causal relations.

Keywords: Insulin like growth factor-1, Insulin-like growth factor-binding protein-3, ِِِDiabetes mellitus, Chronic kidney disease, Diabetic nephropathy, Glomerular filtration rate

Implication for health policy/practice/research/medical education:

Insulin-like growth factor-1 (IGF-1) is a potent mitogen for glomerular mesangial cells, and consequently, it can promote the development of the chronic kidney disease (CKD) in patients with diabetes. However, data on the interconnections between IGF1 and CKD in different clinical groups are limited and contradictory. In this study we examined patients with type 2 diabetes and different degrees of renal dysfunction and demonstrated an independent association between the levels of glomerular filtration rate (GFR) and IGF-1, as well as the absence of an independent association between the levels of GFR and insulin-like growth factor-binding protein-3.

Please cite this paper as: Vasilkova VN, Mokhort TV, Pchelin IY, Bayrasheva VK, Naumenko EP, Korotaeva LE, et al. Association between serum insulin like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 levels and chronic kidney disease in diabetic patients. J Renal Inj Prev. 2021; 10(1): e05. doi: 10.34172/jrip.2021.05.

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