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Submitted: 20 May 2020
Accepted: 03 Jul 2020
ePublished: 24 Jul 2020
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J Renal Inj Prev. 2021;10(1): e06.
doi: 10.34172/jrip.2021.06
  Abstract View: 73
  PDF Download: 36

Original Article

Correlation between blood lead level and anemia in hemodialysis patients

Parisa Mohammadi 1, Farid Azizi Jalilian 2 ORCID logo, Hassan Ahmadinia 3 ORCID logo, vida Sheikh 1,4 * ORCID logo

1 Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
4 Clinical Research Development Unit of Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding author: Vida Sheikh, Email; v.sheikh@umsha.ac.ir

Abstract

Introduction: Studies show that blood lead level (BLL) is higher in hemodialysis patients than in healthy people. Lead can disrupt iron metabolism and hemoglobin synthesis and therefore it is regarded as a cause of anemia.

Objectives: This study investigated the relationship between BLL and anemia in end-stage renal disease (ESRD) undergoing maintenance hemodialysis

Patients and Methods: This case-control study was conducted on 70 patients who had received hemodialysis at least for three months. The participants were selected randomly among eligible patients considering the inclusion and exclusion criteria. Based on their hemoglobin levels, the participants were divided into two groups, namely patients with anemia (case) and those without anemia (control).

Results: The mean age of the participants in the case and control groups were 63.8±11.02 and 55.4±13.34 years, respectively. There were significant differences between two groups regarding hemoglobin, C-reactive protein (CRP) and erythropoietin (EPo) levels (P < 0.05). There was a significant correlation between hemoglobin and ferritin levels in the case group and between the length of dialysis and serum iron level in the control group without anemia (P < 0.001).

Conclusion: Our results showed no correlation between BLL and anemia, however the BLL was higher in those undergoing long-term maintenance hemodialysis. Our findings require further investigation with larger studies.

Keywords: Anemia, Blood lead level, End-stage renal disease, Hemodialysis

Implication for health policy/practice/research/medical education:

To investigate the relationship between blood lead level and anemia in end-stage renal disease undergoing maintenance hemodialysis, we conducted a case-control study on 70 patients. No correlation between lead level and anemia was detected, however the blood lead level was higher in those undergoing long-term maintenance hemodialysis.

Please cite this paper as: Mohammadi P, Azizi Jalilian F, Ahmadinia H, Sheikh V. Correlation between blood lead level and anemia in hemodialysis patients. J Renal Inj Prev. 2021; 10(1): e06. doi: 10.34172/jrip.2021.06.

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