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Submitted: 16 Dec 2020
Accepted: 03 Feb 2020
ePublished: 17 Feb 2020
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J Renal Inj Prev. 2020;9(3): e24.
doi: 10.34172/jrip.2020.24
  Abstract View: 109
  PDF Download: 57

Original

Comparative study of albumin 5% solution with Ringer’s lactate for substitute blood loss of intraoperation on the integrity of the patient’s coagulation system, renal function and electrolytes after surgery; a double-blind clinical trial study

Hossein Madinah 1 * ORCID logo, Gholamreza Shabaniyan 1 ORCID logo, Mehdi Hadadzadeh 1 ORCID logo

1 Department of Anesthesia, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Hossein Madinah, Email: madineh@skums.ac.ir and hosseinmadineh@gmail.com

Abstract

Introduction: The type of fluid replace sufficient volume loss during surgery is crucial for normal renal functioning.

Objectives: The aim of this study was to compare the effect of albumin 5% infusion versus Ringer’s lactate solution on substitution of intraoperative bleeding on the status of the patient’s hemodynamic and coagulation system after surgery.

Patients and Methods: This clinical trial study was performed on 80 patients with nonemergency surgery with the possibility of intraoperative bleeding. Bleeding replacement was performed in the control group with Ringer’s lactate serum and in the case group was replaced with 5% albumin. Patients’ coagulation status (prothrombin time [PT] and relative thromboplastin time and international normalized ratio; INR), electrolyte concentrations (sodium, potassium, and calcium), renal activity tests (serum urea and creatinine) were performed before and at 6, 12, and 24 hours after anesthesia.

Results: The results of the study showed no significant difference between the two groups regarding renal parameters, electrolytes (sodium, potassium and calcium) in all stages of the study. Additionally, PT and partial thromboplastin time (PPT) at 6, 12, and 24 hours postoperation in albumin receiving group was less than that of the Ringer’s lactate group (P <0.01). Additionally, 12 and 24 hours after operation, the INR was significantly less in the albumin group compared to Ringer’s lactate serum receiver (P<0.05).

Conclusion: This study showed that the administration of albumin solution in comparison with Ringer’s lactate for replacement of intraoperative bleeding reduces the risk of bleeding after surgery due to less coagulation disorder.

Keywords: Albumin, Ringer’s lactate, Prothrombin time (PT), Partial thromboplastin time, International normalized ratio

Implication for health policy/practice/research/medical education:

To compare the effect of albumin 5% infusion versus Ringer’s lactate solution on substitution of intraoperative bleeding on the status of the patient’s hemodynamic and coagulation system after surgery, we conducted a clinical trial study on 80 patients with non-emergency surgery. We found that the administration of albumin solution in comparison with Ringer’s lactate for replacement of intraoperative bleeding reduces the risk of bleeding after surgery due to less coagulation disorder..

Please cite this paper as: Madinah H, Shabaniyan G, Hadadzadeh M. Comparative study of albumin 5% solution with Ringer’s lactate for substitute blood loss of intra-operation on the integrity of the patient’s coagulation system, renal function and electrolytes after surgery; a double-blind clinical trial study. J Renal Inj Prev. 2020; 9(3): e24. doi: 10.34172/jrip.2020.24.

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