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Submitted: 07 Apr 2020
Accepted: 17 May 2020
ePublished: 29 May 2020
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J Renal Inj Prev. 2020;9(4): e29.
doi: 10.34172/jrip.2020.29
  Abstract View: 368
  PDF Download: 155

Mini-Review

Does exercise training attenuate cisplatin nephrotoxicity?

Mina Kafashi 1 ORCID logo, Mohammad Reza Kaffashian 2 ORCID logo, Mehdi Nematbakhsh 3,4 ORCID logo, Maryam Maleki 2 * ORCID logo, Tahereh Safari 5,6 * ORCID logo

1 Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
2 Department of Physiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
3 Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Water and Electrolytes Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
6 Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
*Corresponding authors: Maryam Maleki, Ph.D, Email: maleki-m@medilam.com, and Tahereh Safari, PhD, Email: maleki-m@medilam.ac.ir

Abstract

Cisplatin (CP), a medication originating from the platinum has been used for solid cancers’ treatment in the last decade. CP is associated with numerous side effects as well. One of the side effects is nephrotoxicity. There are some types of procedure which can attenuate harmful effects of the drug, and the effectiveness of physical activity has been a controversial topic. It is well established that physical activity has positive effects on chronic kidney disease (CKD). The exercise training can modulate CP induced muscle wasting both in males and females. Although exercise training may have protective effect on renal function and the related risk factors, it cannot attenuate the renal injury resulted from CP therapy in females. The exercise training may improve interleukin 6 and heme oxygenase-1, reduces the production of CD4+T cell cytokines from the kidney, which play a major role in adaptive immune response. The present mini-review considered the effect of exercise training accompanied by the CP treatment.
Keywords: Aerobic training, Acute kidney injury, Nephrotoxicity, Cisplatin

Implication for health policy/practice/research/medical education:

Cisplatin (CP), is one of the most prevalence and effective medications applied to treat numerous cancer. Recently, researches have focued on the attenuation of CP therapy risk factors, which one of these adjusters is exercise training.

Please cite this paper as: Kafashi M, Kaffashian MR, Nematbakhsh MN, Maleki M, Safari T. Does exercise training attenuate cisplatin nephrotoxicity? J Renal Inj Prev. 2020; 9(4): e29. doi: 10.34172/jrip.2020.29.

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