Submitted: 09 Sep 2020
Accepted: 04 Oct 2020
ePublished: 29 Oct 2020
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J Renal Inj Prev. 2021;10(2): e13.
doi: 10.34172/jrip.2021.13
  Abstract View: 58
  PDF Download: 18


Long-term effects of hyperproteic diet on functional renal reserve and natriuresis

Edwin R. Castillo Velarde * ORCID logo

1 Universidad Ricardo Palma, Lima, PerĂº


Introduction: A hyperproteic diet normally results in acute changes in renal function evidenced by increases of natriuresis and glomerular filtration rate (renal functional reserve).Objectives: To assess the changes in natriuresis and creatinine clearance during 12 weeks on hyperproteic and hypersodic diet.

Materials and Methods: Eighteen adults male Holtzman rats were included and the follow-up period was 12 weeks. The rats were initially distributed into three groups; hyperproteic diet (30%) from an animal source (n = 6), hyperproteic diet (30%) from a plant source (n = 6) and normoproteic diet (18%) from an animal source (n = 6). The diets were isocaloric, normosodic (0.25%). From week 8, each group was divided into three rats each and received a high-sodium (1.5%) and normosodic diet (0.25%) respectively.

Results: The hyperproteic diet group (animal or plant vegetal source) had higher creatinine clearance than normoproteic diet (P < 0.05). The hyperproteic vegetal diet group had a peak with an increased renal functional reserve in 21% (P = 0.04). The natriuresis increased in the group on the animal-source diet during the first 2 weeks (P = 0.03). The group plant-source diet did not have significant change at the first week (P = 0.50); however, there was a subsequent decrease in the level of natriuresis between weeks 3 to 8. When the groups were exposed to a hypersodic diet, there was not difference in the natriuretic response between the groups (P > 0.05).

Conclusion: A hyperproteic vegetal diet increased renal functional reserve but not natriuresis during an acute or long-term period; however, the natriuretic response was not impaired when a hypersodic diet was added, though hyperfiltration was present.

Keywords: Hyperproteic diet, Hypersodic diet, Glomerular filtration rate, Natriuresis, Renal functional reserve
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