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Submitted: 14 Feb 2021
Accepted: 09 Mar 2021
ePublished: 02 Apr 2021
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J Renal Inj Prev. 2021;10(3): e17.
doi: 10.34172/jrip.2021.17
  Abstract View: 55
  PDF Download: 38

Review

Epidemiological, clinical and morphological aspects of kidney damage in COVID-19

Batir Daminov ORCID logo, Sherzod Abdullaev * ORCID logo, Olimkhon Sharapov ORCID logo, Ranokhon Igamberdieva ORCID logo

1 Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan
*Corresponding author: Sherzod Abdullaev, Email: sh.abdullayev@tashpmi.uz, Sherzod.abdullaev83@gmail.com

Abstract

The mini-review presents modern data on the epidemiology, clinical and morphological aspects of kidney damage in COVID-19. Potential mechanisms of kidney involvement in the clinical picture of the disease may include cytokine damage, cross-organ damage, and systemic effects that determine the treatment strategy. These mechanisms are closely interrelated and are especially important for individuals undergoing extracorporeal therapy and kidney transplants. Autopsy data provide evidence of SARS-CoV-2 virus invasion into kidney tissue with damage to tubular epithelial cells and podocytes, and erythrocyte aggregation in persons with severe COVID-19. By including people with chronic kidney disease in planned COVID-19 research protocols, an evidence base for effective and safe treatments can be generated.
Keywords: SARS-CoV-2, COVID-19, Pandemic, Kidney disease, Coronavirus infection, Chronic kidney disease, Acute renal failure

Implication for health policy/practice/research/medical education:

In this mini review we tried to clarify epidemiological, clinical and morphological aspects of kidney damage in COVID-19. Kidney diseases are one of the main common complications of COVID-19 and a significant risk factor for death. Therefore, monitoring of kidney function should begin in patients with mild respiratory symptoms of COVID-19.

Please cite this paper as: Daminov B, Abdullaev S, Sharapov O, Igamberdieva R. Epidemiological, clinical and morphological aspects of kidney damage in COVID-19. J Renal Inj Prev. 2021;10(3): e17. doi: 10.34172/jrip.2021.17.


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