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Submitted: 10 Jul 2021
Accepted: 05 Jun 2022
ePublished: 09 Jun 2022
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J Renal Inj Prev. 2022;11(3): e31933.
doi: 10.34172/jrip.2022.31933
  Abstract View: 309
  PDF Download: 156

Review

The effect of olive leaf use on blood pressure; A systematic review and meta-analysis

Alireza Fatahian 1 ORCID logo, Seyde Sedighe Yousefi 2 ORCID logo, Mohammad Azadbakht 3,4 ORCID logo, Mahmood Moosazadeh 5* ORCID logo, Moloud Fakhri 4* ORCID logo

1 Department of Cardiology, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2 Department of Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
4 Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
5 Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
*Corresponding Authors: Corresponding author: Mahmood Moosazadeh, Email: , Email: mmoosazadeh1351@mazums.ac.ir; Corresponding author: Moloud Fakhri, Email: mmfir@yahoo.com, , Email: m.fakhri@mazums.ac.ir

Abstract

Context: Hypertension has been identified as the world’s third leading cause of death. Due to their cost-effectiveness and lack of adverse effects compared to antihypertensive medications, medicinal plants have gained popularity in most countries. The olive leaf is one of these plants. As a result, the purpose of the current systematic review and meta-analysis was to determine the effect of olive leaf consumption on systolic and diastolic blood pressure.

Evidence acquisition: The following domestic and international databases were searched in order to retrieve relevant studies: PubMed, Scopus, Web of Science, Embase, Cochrane, ProQuest, and Google Scholar search engine, the ClinicalTrials.gov Protocol Registration and Results System (PRS), the ISRCTN registry administered by BioMed Central, and the World Health Organization’s (WHO) International Clinical Trials Registry Platform. The data collected were analyzed using STATA software (version14) at a significance level of P<0.05.

Results: Olive leaf consumption had a significant effect on systolic blood pressure [-0.87 (95% CI: -1.09, -0.64)] and diastolic blood pressure [-0.39 (95% CI: -0.57, -0.21)] in five studies with a sample size of 145 people (mean age range of 33.30 ± 5.25 years). Consumption of olive leaves also decreased cholesterol levels [-0.52 (95% CI: -0.81, -0.22)], low-density lipoprotein (LDL-c) levels [-0.35 (95% CI: -0.58, -0.12)], and triglycerides levels [-0.67 (95% CI: -1.19, -0.16)]. Nonetheless, the olive leaf had no statistically significant effect on reducing highdensity lipoprotein levels.

Conclusion: We observed that olive leaf consumption significantly reduced the levels of systolic and diastolic blood pressure, cholesterol, triglycerides, and LDL-c.

Registration: The current protocol was also registered on PROSPERO (ID: 221277, Date: 16.04.2022).


Implication for health policy/practice/research/medical education:

Olive leaf consumption had a significant effect on systolic blood pressure [-0.87 (95% CI; -1.09, -0.64)] and diastolic blood pressure [-0.39 (95% CI; -0.57, -0.21)] in five studies with a sample size of 145 people (mean age range of 33.30 ± 5.25 years). Consumption of olive leaves also decreased cholesterol levels [-0.52 (95% CI; -0.81, -0.22)], low-density lipoprotein (LDL-c) levels [-0.35 (95% CI; -0.58, -0.12)], and triglycerides levels [-0.67 (95% CI; -1.19, -0.16)]. Nonetheless, the olive leaf had no statistically significant effect on reducing high-density lipoprotein levels.

Please cite this paper as: Fatahian A, Yousefi SS, Azadbakht M, Moosazadeh M, Fakhri M. The effect of olive leaf use on blood pressure; A systematic review and meta-analysis. J Renal Inj Prev. 2022; 11(3): e31933. doi: 10.34172/jrip.2022.31933.

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