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Submitted: 27 Oct 2021
Accepted: 11 Dec 2021
ePublished: 24 Apr 2022
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J Renal Inj Prev. 2022;11(3): e31976.
doi: 10.34172/jrip.2022.31976
  Abstract View: 296
  PDF Download: 120

Original

IL-17 gene polymorphism (rs763780) in kidney recipients with post-transplant diabetes

Sepideh Zununi Vahed 1 ORCID logo, Jalal Etemadi 1 ORCID logo, Taraneh Majidi 1, Seyyedeh Mina Hejazian 1,2 ORCID logo, Paria Ronaghi 1,2, Mohammadreza Ardalan 1* ORCID logo

1 Kidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: *Corresponding author: Prof. Mohammadreza Ardalan, Emails: ardalan34@yahoo.com, , Email: ardalanm@tbzmed.ac.ir

Abstract

Introduction: New-onset diabetes mellitus after transplantation (NODAT) is a common complication of organ transplantation, leading to allograft dysfunction. Genetic alterations of inflammatory cytokines have been reported to be associated with glucose homeostasis and diabetes.

Objectives: This study evaluated the rs763780 polymorphism of IL-17F gene in transplant recipients with and without NODAT.

Patients and Methods: The present retrospective study was conducted on ninety-one patients who have had a kidney transplant for at least three months. Patients were divided into two subgroups; recipients with NODAT (n=32) and kidney recipients without NODAT (n=59). After DNA extraction from patients’ blood samples, amplification and evaluation of specific polymorphism of the gene were performed using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Clinical and demographic data of patients were collected.

Results: The NODAT was detected in 81.3% (n=26) of TT genotype carriers, 12.5% of TC genotype carriers and 6.3% of CC genotype carriers. No statistically significant differences between the studied groups in the frequency of C and T alleles and the distribution of the abovementioned genotypes were detected (P≥0.721). In the NODAT group, graft rejection and age of patients were higher significantly (P≤0.017).

Conclusion: No significant correlation between the incidence of diabetes and rs763780 polymorphism of IL-17F gene was observed.


Implication for health policy/practice/research/medical education:

Dysfunction of pancreatic β-cells, insulin resistance, oxidative stress and low-grade chronic inflammation play important roles in the development of new-onset diabetes mellitus after transplantation (NODAT) among kidney transplant recipients. IL-17 polymorphisms impact on the pathogenesis of NODAT and variations in IL-17R is connected with type 1 diabetes (T1D) that are reported to be associated with the pathogenesis of NODAT.

Please cite this paper as: Zununi Vahed S, Etemadi J, Majidi T, Hejazian SM, Ronaghi P, Ardalan M. IL-17 gene polymorphism (rs763780) in kidney recipients with post-transplant diabetes. J Renal Inj Prev. 2022; 11(3): e31976. doi: 10.34172/jrip.2022.31976.

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