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Submitted: 09 Nov 2021
Accepted: 26 Mar 2022
ePublished: 28 May 2022
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J Renal Inj Prev. 2022;11(3): e31984.
doi: 10.34172/jrip.2022.31984
  Abstract View: 254
  PDF Download: 110

Original

Effect of vitamin D treatment on magnesium levels in chronic hemodialysis patient; a double blind controlled clinical trial

Shahla Ahmadi Halili 1 ORCID logo, Ali Ghorbani 1 ORCID logo, Ebrahim Hamreh 2* ORCID logo, Leila Sabetnia 1 ORCID logo, Fatemeh Hayati 1 ORCID logo, Khojasteh Hoseinynejad 3 ORCID logo

1 Department of Internal Medicine, School of Medicine, Chronic Renal Failure Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Physiology, Faculty of Medicine, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Author: *Corresponding author: Ebrahim Hamreh, Email: , Email: Hamreh.e@ajums.ac.ir

Abstract

Introduction: The homeostasis of magnesium (Mg) is impaired in chronic kidney disease (CKD) and it has been suggested that intestinal absorption of Mg may be affected by vitamin D status. 25-Hydroxy vitamin D or 25(OH)D deficiency is common in patients undergoing chronic hemodialysis; however the efficacy of nutritional vitamin D supplementation on Mg level in this population remains uncertain.

Objectives: The aim of this study was to evaluate the effect of vitamin D treatment on Mg levels in chronic hemodialysis patients.

Patients and Methods: This randomized clinical trial study was conducted on 69 chronic hemodialysis patients (mean age of 56.93 ±12.26 years) with serum 25-hydroxy vitamin D levels <30 ng/mL. The patients were randomly assigned to one of treatment groups of oral vitamin D3- 50 000 units per week (n=35; experimental group) or 500 mg calcium D3 tablets, every 12 hours (n=34; control group) for three months. At the beginning and end of the treatment period, the levels of serum 25-hydroxy vitamin D and the levels of Mg, calcium, phosphorus and intact parathyroid hormone (iPTH) were measured in two groups.

Results: In both groups, serum vitamin D levels increased significantly after treatment (P<0.0001 for both groups), however after three months of treatment, in the experimental group the levels of vitamin D were significantly higher than the patients in the control group (57 ng/mL versus 28 ng/mL; P<0.0001) and the median increase of vitamin D after treatment in the experimental group was significantly higher than the control group (40 ng/mL versus 10.5; P<0.0001). Serum Mg levels before and after treatment were not significantly different between two groups (P=0.880 and P=0.434). In this study, we found no significant correlation between serum vitamin D level with serum Mg, calcium, phosphate, and parathyroid Hormone levels (P>0.05).

Conclusion: Our study shows that oral vitamin D therapy can increase 25(OH)D levels in maintenance hemodialysis patients without significant alterations in serum calcium, phosphate, magnesium and parathyroid hormone during a 12-week period.

Trial Registration: Registration of trial protocol has been approved by the Iranian registry of clinical trial (#IRCT20210314050698N1; https://en.irct.ir/trial/55159, local ethical code# IR.SKUMS.REC.1397.181).


Implication for health policy/practice/research/medical education:

In a randomized clinical trial study conducted on 69 chronic hemodialysis patients, we found administration of oral vitamin D for 12 weeks may raise 25(OH)D levels in patients of chronic hemodialysis however, it has no significant effect on serum magnesium, calcium, phosphorus and parathyroid hormone levels. We concluded that other factors besides vitamin D are involved in magnesium regulation in hemodialysis patients.

Please cite this paper as: Ahmadi Halili S, Ghorbani A, Hamreh E, Sabetnia L, Hayati F, Hoseinynejad K. Effect of vitamin D treatment on magnesium levels in chronic hemodialysis patient; a double blind controlled clinical trial. J Renal Inj Prev. 2022; 11(3): e31984. doi: 10.34172/jrip.2022.31984.

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