Logo-jrip
Submitted: 21 Feb 2022
Accepted: 19 May 2022
ePublished: 31 May 2022
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Renal Inj Prev. 2022;11(3): e32031.
doi: 10.34172/jrip.2022.32031
  Abstract View: 276
  PDF Download: 135

Original

Is there any association between pentraxin-3, highly sensitive C-reactive protein and mannose-binding lectin with cardiovascular complications in hemodialysis patients?

Alireza Firouzjahi 1 ORCID logo, Reyhaneh Ramezanzade 2 ORCID logo, Simin Mouodi 3 ORCID logo, Hossein Ghorbani 1 ORCID logo, Karimollah Hajian Tilaki 4 ORCID logo, Mehrdad Saravi 5 ORCID logo, Roghayeh Akbari 6* ORCID logo

1 Department of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
2 Department of Pathology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3 Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
4 Department of Epidemiology and Biostatistics, School of Public Health, Babol University of Medical Sciences, Babol, Iran
5 Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
6 Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
7 Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
*Corresponding Author: *Corresponding author: Roghayeh Akbari, Email: roghayeh.akbari@yahoo.com, , Email: r.akbari@mubabol.ac.ir

Abstract

Introduction: The impact of cardiovascular disorders on morbidity and mortality of hemodialysis (HD) patients is considerable. Several markers have been investigated for renal disease and kidney transplantation.

Objectives: The aim of this study was to assess the correlation between three inflammatory biomarkers including pentraxin-3 (PTX-3), highly sensitive C-reactive protein (hs-CRP), and mannose-binding lectin (MBL) with cardiovascular disease (CVD) events and mortality in HD patients.

Patients and Methods: This longitudinal study was conducted on 18-80 years-old chronic kidney disease patients undergoing HD. The participants were followed every six months for 12 months and the occurrence of CVD events was determined with the calculation of left ventricular ejection fraction (LVEF) through echocardiography.

Results: Among 90 patients with a mean age of 54.0±3.24 years, MBL and PTX-3 showed a significant correlation to detect CVD events (r=0.987; P<0.001). The mean PTX-3, MBL and hs-CRP levels were not significantly different among the three ejection fraction groups (P>0.05), since none of these markers reached statistical significance for the prediction of mortality (P>0.05). A significant correlation was found between PTX-3, MBL and hs-CRP, while all of these markers increased in patients with cardiovascular complications (P<0.05).

Conclusion: In our study, PTX-3, MBL and hs-CRP significantly increased in HD patients who had LVEF with decreasing value. The serum concentration of PTX-3 MBL and hs-CRP can be considered a diagnostic tool for early detection of CVD events in end-stage renal disease (ESRD) patients.


Implication for health policy/practice/research/medical education:

In a longitudinal study of a group of HD patients, we found a significant correlation between PTX-3, MBL and hs-CRP and all of these markers increased in patients with cardiovascular complications (P<0.05). The mean PTX-3, MBL and hs-CRP were not significantly different among the three ejection fraction groups (P>0.05) and none of these markers reached statistical significance for the prediction of mortality (P>0.05).

Please cite this paper as: Firouzjahi A, Ramezanzade R, Mouodi S, Ghorbani H, Hajian Tilaki K, Saravi M, Akbari R. Is there any association between pentraxin-3, highly sensitive C-reactive protein and mannose-binding lectin with cardiovascular complications in hemodialysis patients? J Renal Inj Prev. 2022; 11(3): e32031. doi: 10.34172/jrip.2022.32031.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 277

Your browser does not support the canvas element.


PDF Download: 135

Your browser does not support the canvas element.