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Submitted: 08 Jul 2017
Accepted: 15 Nov 2017
ePublished: 26 Nov 2017
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J Renal Inj Prev. 2018;7(1): 22-26.
doi: 10.15171/jrip.2018.05

Scopus ID: 85042613865
  Abstract View: 1880
  PDF Download: 926

Original

Comparison of clinical and histopathological findings in patients with lupus nephritis having IgG deposits versus patients without IgG deposits in renal biopsies

Hina Tariq 1 * , Humaira Nasir 1, Aniqa Khalid Kazi 2, Alishba Khan 2

1 Histopathology Department, Shifa International Hospital, Islamabad, Pakistan
2 Shifa College of Medicine, Islamabad, Pakistan
*Corresponding author: Hina Tariq, dr.hina2013@gmail.com

Abstract

Introduction: Up to 10% of lupus nephritis (LN) do not show IgG deposition of immunofluorescence (IF). Our rationale is to find out whether there is any significant difference in clinical presentation and histopathological findings in both groups of patients.

Objectives: To compare clinical and histopathological findings in patients with LN having IgG deposits versus patients without IgG deposits in renal biopsies.

Patients and Methods: Two groups of IgG positive and IgG negative were made and their details were recorded. Data were analyzed by SPSS 20. Fischer’s exact test was applied to determine significance of above mentioned clinical and laboratory findings with/without IgG deposits in renal biopsies.

Results: Fischer’s exact test results’ for all variables was as follows; M: F ratio was 0.5, edema 0.10, deranged RFT 0.3, hematuria 0.10, proteinuria 0.4, anti-double stranded DNA antibody 0.3 and anti-nuclear antibody 0.5. The P values of LN were class II 0.003, class III 0.8 and class IV 0.3. These findings show that groups with no IgG deposits on IF, present with milder clinical disease.

Conclusion: There was a marginal significant P value for hematuria, edema and LN class II, pointing towards the fact that relatively milder disease in IgG negative group as compared to IgG positive group.

Keywords: Histopathological findings, IgG deposits, Lupus nephritis, Renal biopsy

Implication for health policy/practice/research/medical education:

Article has pointed towards the fact that even in small percentage of cases without IgG deposits on immunofluorescence, clinical and histopathological findings have no significant difference from cases with IgG deposits.

Please cite this paper as: Tariq H, Nasir H, Kazi AK, Khan A. Comparison of clinical and histopathological findings in patients with lupus nephritis having IgG deposits versus patients without IgG deposits in renal biopsies. J Renal Inj Prev. 2018;7(1):22-26. DOI: 10.15171/jrip.2018.05. 

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