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Submitted: 29 Jul 2017
Accepted: 01 Nov 2017
ePublished: 08 Dec 2017
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J Renal Inj Prev. 2018;7(2): 69-72.
doi: 10.15171/jrip.2018.17

Scopus ID: 85044779425
  Abstract View: 1497
  PDF Download: 949

Brief Communication

High-salt intake during pregnancy may influence the outcome of renal ischemia/reperfusion in in adult offspring

Felora Shahzamani 1,2, Ramesh Monajemi, Mehdi Nematbakhsh 1,3,4 *

1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
3 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
4 IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran
*Corresponding author: Prof. Mehdi Nematbakhsh, Ph.D; nematbakhsh@med.mui.ac.ir

Abstract

Introduction: The salt diet during the pregnancy may disturb the adult offspring’s organs functions.

Objectives: This study was designed to determine the role of high salt intake during pregnancy on the outcome of renal ischemia reperfusion (IR) in adult offspring.

Materials and Methods: Renal IR was induced in 55 adult male and female offspring from mothers who intake high salt or normal drinking water during pregnancy, and the kidney function was evaluated.

Results: Salt intake during pregnancy increased the serum levels of creatinine (Cr) and blood urea nitrogen (BUN) and decreased creatinine clearances (ClCr) level in offspring after renal IR gender dependently.

Conclusion: The structural change in kidney of offspring from mothers who were subjected to salt intake during pregnancy may influence the outcomes of offspring’s kidney functions after renal IR.

Keywords: Salt diet, Pregnancy, Offspring, Ischemia/reperfusion

Implication for health policy/practice/research/medical education:

The structural change in kidney of offspring form mothers who were subjected to salt intake during pregnancy may influence the outcomes of offspring’s kidney functions after renal ischemia reperfusion (I/R).

Please cite this paper as: Shahzamani F, Monajemi R, Nematbakhsh M. High-salt intake during pregnancy may influence the outcome of renal ischemia/reperfusion in in adult offspring. J Renal Inj Prev. 2018;7(2):69-72. DOI: 10.15171/jrip.2018.17.

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