Submitted: 20 Aug 2017
Accepted: 07 Dec 2017
ePublished: 14 Jan 2018
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J Renal Inj Prev. 2018;7(2): 73-77.
doi: 10.15171/jrip.2018.18

Scopus ID: 85044726577
  Abstract View: 1844
  PDF Download: 1148


Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects 

Amin Hasanvand 1, Ali Kharazmkia 1, Samareh Mir 1, Reza Mohammadrezaei Khorramabadi 2, Saeideh Darabi 3 *

1 Nutritional Health Research Center, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
3 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Corresponding author: Saeideh Darabi Dr.darabis@yahoo.com


Introduction: The nephrotoxicity of gentamicin is thought to be a dangerous side effect in the use of this drug caused by the formation of oxidative stress and the production of reactive oxygen species (ROS) and nitrogen species. Antioxidant agents play important roles in reducing oxidative stress.

Objectives: In this study, the antioxidant role of ferulic acid has been studied in nephrotoxicity caused by gentamicin.

Materials and Methods: In this experimental study, 50 Spraque-Dawley rats were randomly divided into 5 groups. The first group was considered as the control group and other groups received different doses of ferulic acid + 80 mg/kg gentamycin for 8 days by intraperitoneally injection. After the treatment, blood samples were prepared from animals. Then, the right and left kidneys were removed, paraffin blocks prepared, and the rest of the tissues were lysed. Three samples were used to evaluate serum creatinine and urea, as well as urine creatinine, histopathologic status and oxidative stress factors levels, respectively. To compare the results of different groups, Mann-Whitney U test was used.

Results: Ferulic acid treatment decreased tissue malondialdehyde (MDA), serum urea and creatinine, urine albumin/creatinine ratio and neutrophil gelatinase-associated lipocalin (NGAL), and also increased superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). Ferulic acid reduced tubular necrosis and eosinophilic casts in gentamycin group induced nephrotoxicity.

Conclusion: Ferulic acid can be effective in inhibiting gentamicin-induced nephrotoxicity.

Keywords: Gentamicin, Nephrotoxicity, Ferulic acid, Free radicals, Acute renal failure
Please cite this paper as: Hasanvand A, Mir S, Mohammadrezaei Khorramabadi R, Darabi S. Ameliorative effect of ferulic acid on gentamicin-induced nephrotoxicity in a rat model; role of antioxidant effects. J Renal Inj Prev. 2018;7(2):73-77. DOI: 10.15171/jrip.2018.18.
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