Submitted: 10 Feb 2019
Accepted: 09 Jun 2018
First published online: 06 Jul 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

J Renal Inj Prev. 2019;8(2):71-77.
doi: 10.15171/jrip.2019.14
  Abstract View: 147
  PDF Download: 144

Original

Selenium effects on antioxidant and inflammatory indices in renal ischemia-reperfusion injury in rats

Hassan Ahmadvand 1,2, Esmaeel Babaeenezhad 3,4 * , Hashem Nayeri 5, Zahra Zarei Nezhad 5

1 Razi Herbal Medicine Research Center, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Student of Veterinary Medicine, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
5 Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
*Corresponding author: Esmaeel Babaeenezhad, Email: Es.babaeenezhad1391@gmail.com

Article

Introduction: Selenium (Se) is an antioxidant and reactive oxygen species (ROS) scavenger.

Objectives: This study was conducted to evaluate the effects of Se on renal functional parameters, oxidative stress biomarkers, myeloperoxidase (MPO) activity, and the nitric oxide (NO) level in renal ischemia-reperfusion (IR) injury in rats.

Materials and Methods: Twenty-four male Wistar rats (180–200 g) were selected and subsequently divided into three groups (n=8); group 1 as the control group, group 2 as the untreated group (IR without treatment) and group 3 as the IR group (treated with Se (1 mg/kg/d, intraperitoneally). The period of Se administration was 2 weeks before the inducing renal IR. To cause renal IR, renal pedicles were occluded by safe clamps for 45 minutes. Then, the clamps were removed and 24 hours was considered as reperfusion. After the study, blood sampling from the hearts and the removal of the left kidney was conducted immediately for biochemical measurements.

Results: Renal IR significantly increased serum levels of urea, creatinine (Cr), serum and renal malondialdehyde (MDA) levels, serum NO level, and MPO activity. It significantly decreased serum and renal glutathione (GSH) levels, serum paraoxonase 1 activity, serum and renal activities of catalase (CAT), and glutathione peroxidase (GPx). Se could reverse these findings, but the increase of paraoxonase 1 activity and the decrease of MPO activity in IR animals were not significant.

Conclusion: It seems that Se has protective effects on inflammatory indices. It can ameliorate renal IR complications which are associated with oxidative stress and inflammation.

Implication for health policy/practice/research/medical education:

Our study indicated that Se could ameliorate Cr and urea, LPO, the activities of antioxidant enzymes, the levels of GSH, NO, and MPO activity in IR treated group. All of the authors wish, the results of this study help to improve complications related to the renal ischemia reperfusion in the patients.

Please cite this paper as: Ahmadvand H, Babaeenezhad E, Nayeri H, Zarei Nezhad Z. Selenium effects on antioxidant and inflammatory indices in renal ischemia-reperfusion injury in rats. J Renal Inj Prev. 2019;8(2):71-77. DOI: 10.15171/jrip.2019.14.

First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 147

Your browser does not support the canvas element.


PDF Downloaded: 144

Your browser does not support the canvas element.