Submitted: 10 Feb 2018
Accepted: 03 Aug 2018
First published online: 23 Aug 2018
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J Renal Inj Prev. 2019;8(2):91-97.
doi: 10.15171/jrip.2019.18
  Abstract View: 45
  PDF Download: 45

Original

Glutathione ameliorates liver markers, oxidative stress and inflammatory indices in rats with renal ischemia reperfusion injury

Hassan Ahmadvand 1,2, Esmaeel Babaeenezhad 3,4 * , Maryam Nasri 3, Leila Jafaripour 5, Reza Mohammadrezaei Khorramabadi 3

1 Razi Herbal Medicine Research Center, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Student of Veterinary Medicine, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
5 Department of Anatomy, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran
*Corresponding author: Esmaeel Babaeenezhad, Email: Email: Es.babaeenezhad1391@gmail.com

Article

Introduction: Glutathione (GSH) protects the tissue and cell from oxidative injury.

Objectives: In the current study, we investigated the possible effects of GSH on liver markers, oxidative stress and inflammatory indices in rat with renal ischemia reperfusion (RIR) injury.

Materials and Methods: Twenty-four adult male Wistar rats were divided into 3 groups (n=8). Group I (the control group), group II (the RIR group) received saline (0.25 mL/d, intraperitoneally; i.p.), group III as the RIR group that received GSH (100 mg/kg/d, i.p.). The treatment with saline or GSH began daily 14 days before RIR induction. RIR was induced by clamping renal pedicles for 45 minutes and 24 hours of reperfusion.

Results: RIR significantly increased the serum level of nitric oxide (NO), the serum activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), the serum and renal levels of malondialdehyde (MDA), and the serum activity of myeloperoxidase (MPO). However, RIR significantly decreased the serum and renal levels of GSH, serum paraoxonase 1 (PON1) activity, and the serum and renal activities of catalase (CAT) and glutathione peroxidase (GPX). GSH administration could significantly improve the serum activities of AST, GGT, MPO, GPX and PON1 and serum levels of NO, renal MDA, GSH levels, and serum and also renal CAT activities.

Conclusion: Our study indicated that GSH administration ameliorated RIR injury in rats by improving the activities of liver markers and antioxidant enzymes, the levels of MDA, NO, GSH and MPO activity.

Implication for health policy/practice/research/medical education:

Our study indicated that glutathione could ameliorate lipid peroxidation, the activities of liver markers, antioxidant enzymes, and the levels of glutathione, nitric oxide, and myeloperoxidase activity in ischemia reperfusion injury treated group.

Please cite this paper as: Ahmadvand H, Babaeenezhad E, Nasri M, Jafaripour L, Mohammadrezaei Khorramabadi R. Glutathione ameliorates liver markers, oxidative stress and inflammatory indices in rats with renal ischemia reperfusion injury. J Renal Inj Prev. 2019;8(2):91-97. DOI: 10.15171/jrip.2019.18

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