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Submitted: 09 Oct 2017
Accepted: 08 Dec 2017
ePublished: 20 Jan 2018

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Cited By

J Renal Inj Prev. 2018;7(4): 218-223.
doi: 10.15171/jrip.2018.51

Scopus ID: 85054386420
  Abstract View: 1849
  PDF Download: 5831

Review

Potential adverse effects of amphetamines on kidney; a narrative review on current knowledge

Tahmineh Mokhtari 1,2, Ardeshir Sheikhazadi 3, Gholamreza Hassanzadeh 4, Manouchehr Safari 1, Fatemeh Sheikhbahaei 5, Hedyeh Faghir-Ghanesefat 6, Maryam Rezaei 3 *

1 Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
2 Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
3 Department of Forensic Medicine and Toxicology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Anatomical Sciences, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
6 Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding author: Maryam Rezaei, Email: mrezaei@sina.tums.ac.ir

Abstract

This study aims to review the literature pertaining to the renal effects of amphetamines (AMPs) including AMP and its analogues (ARDAs) such as methamphetamine (MET) and 3,4-methylenedioxy-N-methylamphetamine (MDMA) and discuss the implications for these drugs users. The study was performed through searching in the relevant literature. Sufficient clinical and experimental evidence suggested that AMPs have adverse and potentially nonfatal and fatal effects on users’ kidneys. The acute and chronic renal complications due to illicit drugs such as AMPs have been investigated. A few renal effects in AMPs users have been demonstrated. However, isolated reports of adverse renal effects of AMPs including nephropathy due to rhabdomyolysis, necrotizing renal vasculopathy and malignant hypertension have been recorded. It can be suggested that renal damages after AMPs consumption should be considered in the emergency departments (EDs).
Keywords: Acute kidney injury, Amphetamines, Kidney, Drug abuse, Nephropathy, Necrotizing renal vasculopathy

Implication for health policy/practice/research/medical education:

Isolated reports on renal complications, rhabdomyolysis, necrotizing renal maculopathy and malign hypertension, induced by amphetamine (AMP) and its analogues have been recorded. This review tried to survey different sources to collect information for better understanding the pathophysiology underlying the functional defects and different renal complications in patients with AMP abuse.

Please cite this paper as: Mokhtari T, Sheikhazadi A, Hassanzadeh G, Safari M, Sheikhbahaei F, Faghir-Ghanesefat H, et al. Potential adverse effects of amphetamines on kidney; a narrative review on current knowledge. J Renal Inj Prev. 2018;7(4):218- 223. Doi: 10.15171/jrip.2018.51.

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