Submitted: 03 Apr 2019
Accepted: 19 Jun 2019
First published online: 11 Jul 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

J Renal Inj Prev. 2019;8(3):225-229.
doi: 10.15171/jrip.2019.42
  Abstract View: 112
  PDF Download: 99

Original

The effect of artichoke leaf extract supplementation on lipid profile of chronic kidney disease patients; a double-blind, randomized clinical trial

Seyed Mansour Gatmiri 1 ORCiD, Ebrahim Khadem 2 ORCiD, Toktam Fakhrian 3, Mohammad Kamalinejad 4, Hamed Hosseini 5, Fereshteh Ghorat 6, Azam Alamdari 1 * ORCiD, Neda Naderi 1 * ORCiD

1 Nephrology Research Center, Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
3 School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4 School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences
6 School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran † These authors contributed equally

Article

Introduction: Hyperlipidemia is considered a prominent risk factor for coronary heart disease. Coronary heart disease is the most common cause of mortality and morbidity in chronic kidney disease (CKD) patients.

Objectives: The aim of this study was to evaluate the effects of artichoke leaf extract (ALE) supplementation on the lipid profile of CKD patients.

Patients and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 38 CKD subjects (GFR<60 and >15 mL/min/1.73 m2 ) with hypercholesterolemia (total cholesterol ≥ 200 mg/dL or low-density lipoprotein cholesterol [LDL-C] ≥ 110 mg/dL). The intervention group received an artichoke capsule (320 mg) and an indistinguishable placebo was given to the control group twice daily for 6 weeks. Lipid profile and appetite were assessed at week 8 and the results were compared with the baseline data.

Results: ALE supplementation was correlated with a statistically significant decrease in mean total cholesterol (P=0.028) and LDL-C (P=0.005) compared to the control group. The two groups did not show a significant difference in high-density lipoprotein-cholesterol (P=0.071) and triglyceride levels (P=0.22). There was a statistically significant difference in appetite between the two groups (P=0.016).

Conclusion: This randomized controlled trial demonstrated that consumption of ALE supplement may improve appetite and lipid profile in CKD patients.

Implication for health policy/practice/research/medical education:

The aim of this study was to evaluate the effects of ALE supplement on the lipid profile of CKD patients. This randomized controlled trial demonstrated that consumption of ALE supplement may improve lipid profile and appetite in these patients.

Please cite this paper as: Gatmiri SM, Khadem E, Fakhrian T, Kamalinejad M, Hosseini H, Ghorat F, et al. The effect of artichoke leaf extract supplementation on lipid profile of chronic kidney disease patients; a double-blind, randomized clinical trial. J Renal Inj Prev. 2019; 8(3): 225-229. DOI: 10.15171/jrip.2019.42.

First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 112

Your browser does not support the canvas element.


PDF Downloaded: 99

Your browser does not support the canvas element.